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24,25,26-Trinoroleana-1(10),3,5,7-tetraen-29-oic acid, 3-hydroxy-9,13-dimethyl-2-oxo-, 3-(2-chloro-4-nitro-1H-imidazol-1-yl)propyl ester, (9β,13α,14β,20α)- Suppliers list
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:CAY10792
CAS:2361009-68-7
Purity:98% Package:1mg;5mg;10mg
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| Company Name: |
Cayman Chemical Company
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| Tel: |
800-364-9897 |
| Email: |
sales@caymanchem.com |
| Products Intro: |
Product Name:CAY10792
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| Company Name: |
Neobioscience Co., Ltd.
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| Tel: |
4006-800-892 |
| Email: |
info@neobioscience.com |
| Products Intro: |
Product Name:CAY10792
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| Company Name: |
Cayman Chemical Company
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| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:CAY10792
CAS:2361009-68-7
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| | 24,25,26-Trinoroleana-1(10),3,5,7-tetraen-29-oic acid, 3-hydroxy-9,13-dimethyl-2-oxo-, 3-(2-chloro-4-nitro-1H-imidazol-1-yl)propyl ester, (9β,13α,14β,20α)- Basic information |
| Product Name: | 24,25,26-Trinoroleana-1(10),3,5,7-tetraen-29-oic acid, 3-hydroxy-9,13-dimethyl-2-oxo-, 3-(2-chloro-4-nitro-1H-imidazol-1-yl)propyl ester, (9β,13α,14β,20α)- | | Synonyms: | 24,25,26-Trinoroleana-1(10),3,5,7-tetraen-29-oic acid, 3-hydroxy-9,13-dimethyl-2-oxo-, 3-(2-chloro-4-nitro-1H-imidazol-1-yl)propyl ester, (9β,13α,14β,20α)-;CAY10792 | | CAS: | 2361009-68-7 | | MF: | C35H44ClN3O6 | | MW: | 638.2 | | EINECS: | | | Product Categories: | | | Mol File: | 2361009-68-7.mol |  |
| | 24,25,26-Trinoroleana-1(10),3,5,7-tetraen-29-oic acid, 3-hydroxy-9,13-dimethyl-2-oxo-, 3-(2-chloro-4-nitro-1H-imidazol-1-yl)propyl ester, (9β,13α,14β,20α)- Chemical Properties |
| Boiling point | 802.2±75.0 °C(Predicted) | | density | 1.34±0.1 g/cm3(Predicted) | | solubility | Chloroform: Soluble | | form | A crystalline solid | | pka | 8.60±0.70(Predicted) | | color | Light yellow to yellow |
| | 24,25,26-Trinoroleana-1(10),3,5,7-tetraen-29-oic acid, 3-hydroxy-9,13-dimethyl-2-oxo-, 3-(2-chloro-4-nitro-1H-imidazol-1-yl)propyl ester, (9β,13α,14β,20α)- Usage And Synthesis |
| Description | CAY10792 is an anticancer agent.1 It binds to heat shock protein 90 (Hsp90) and cell division cycle 37 (Cdc37) in cell-free assays. CAY10792 inhibits the growth of A549, HCT116, U2OS, and MDA-MB-231 cancer cells (IC50s = 0.54, 0.59, 0.57, and 0.57 μM, respectively) but not A549 cells overexpressing Hsp90, Cdc37, or Hsp90 and Cdc37 (IC50s = >100 μM for all). It induces cell cycle arrest at the G0/G1 phase and apoptosis in A549 lung cancer cells when used at a concentration of 0.8 μM. In vivo, CAY10792 (0.5 and 1 mg/kg) reduces tumor weight in an A549 mouse xenograft model. | | Uses | Hsp90-Cdc37-IN-3 (Compound 9) is a novel celastrol?imidazole derivative with anticancer activity. Hsp90-Cdc37-IN-3 inhibits Hsp90?Cdc37 by covalent-binding, and induces apoptosis[1]. | | in vivo | Hsp90-Cdc37-IN-3 (Compound 9) (0-1 mg/kg; i.p.; once a day, 21 days) shows strong antitumor activity with no significant toxicity[1]. | Animal Model: | Female BALB/c nude mice at 6 weeks old[1]. | | Dosage: | 0.5 mg/kg or 1 mg/kg. Mice were inoculated subcutaneously with A549 cells (1*107 in 100 μL of PBS for each mouse). | | Administration: | Intraperitoneal injection, once a day, 21 days | | Result: | Decreased tumor weight and enhanced TIR without show toxicity. |
| | IC 50 | Hsp90-Cdc37 | | References | 1. Li, N., Xu, M., Zhang, L., et al. Discovery of novel celastrol-imidazole derivatives with anticancer activity in vitro and in vivo J. Med. Chem. 65(6),4578-4589(2022). |
| | 24,25,26-Trinoroleana-1(10),3,5,7-tetraen-29-oic acid, 3-hydroxy-9,13-dimethyl-2-oxo-, 3-(2-chloro-4-nitro-1H-imidazol-1-yl)propyl ester, (9β,13α,14β,20α)- Preparation Products And Raw materials |
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