ophiobolin C

ophiobolin C Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:Ophiobolin C
CAS:19022-51-6
Package:1 mg;5 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: BOC Sciences
Tel: 16314854226; +16314854226
Email: inquiry@bocsci.com
Products Intro: Product Name:Ophiobolin C
CAS:19022-51-6
Purity:>98% by HPLC Remarks:BOC Sciences also provides custom synthesis services for Ophiobolin C.
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:Ophiobolin C
CAS:19022-51-6
Purity:>98% Package:$273.9/1mg;Bulk package Remarks:>98%
Company Name: Lynnchem  
Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Products Intro: Product Name:ophiobolin C
CAS:19022-51-6
Purity:>98% by HPLC Package:1mg;5mg
Company Name: Novachemistry  
Tel: 44-20819178-90 02081917890
Email: info@novachemistry.com
Products Intro: Product Name:Ophiobolin C
CAS:19022-51-6
Purity:>98% by HPLC Package:1mg;5mg
ophiobolin C Basic information
Product Name:ophiobolin C
Synonyms:ophiobolin C;3-Hydroxy-5-oxoophiobola-7,19-dien-25-al;Zizanin A;Dicyclopenta[a,d]cyclooctene-4-carboxaldehyde, 7-[(1S)-1,5-dimethyl-4-hexen-1-yl]-1,2,3,3a,6,6a,7,8,9,9a,10,10a-dodecahydro-1-hydroxy-1,9a-dimethyl-3-oxo-, (1R,3aS,6aS,7R,9aR,10aS)-
CAS:19022-51-6
MF:C25H38O3
MW:386.57
EINECS:
Product Categories:
Mol File:19022-51-6.mol
ophiobolin C Structure
ophiobolin C Chemical Properties
storage temp. Store at -20°C
solubility DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
form A solid
Safety Information
MSDS Information
ophiobolin C Usage And Synthesis
DescriptionOphiobolin C is a sesterterpenoid fungal phytoxin produced by many species of the genus Bipolaris. It has been identified as an antagonist of chemokine receptor CCR5 binding (IC50 = 40 μM) to the envelope protein gp120 and to CD4, which is known to mediate HIV-1 viral entry into cells. Ophiobolin C is also reported to be cytotoxic to chronic lymphocytic leukemia cells (LC50 = 8 nM).
UsesOphiobolin C is an inhibitor of human CCR5 binding to HIV-1 gp120.
UsesOphiobolin C is a member of the ophiobolin class of phytotoxic metabolites produced by many species of the genus Bipolaris. Ophiobolin C inhibits human CCR5 binding to the envelope protein gp120 and CD4 that mediates HIV-1 entry into cells. Blockade of this binding was considered by scientists at Merck as a potential new mode of action for the treatment of HIV-1 infection.
DefinitionChEBI: Ophiobolin C is a sesterterpenoid that is ophiobolane with a hydroxy group at position 3, oxo group at positions 5, formyl group at position 7, and double bonds at positions 7-8 and 19-20. It has a role as an antineoplastic agent, an apoptosis inducer, an Aspergillus metabolite, a chemokine receptor 5 antagonist, a nematicide and a fungal metabolite. It is a cyclic ketone, an enal, a sesterterpenoid, a tertiary alcohol, a carbotricyclic compound and an olefinic compound. It derives from a hydride of an ophiobolane.
ophiobolin C Preparation Products And Raw materials
Tag:ophiobolin C(19022-51-6) Related Product Information
STAUROSPORINE ophiobolin C