| Company Name: |
Shanghai isotope chemical co.,ltd
|
| Tel: |
021-51600108 13062666369 |
| Email: |
sales@isotopechem.com |
| Products Intro: |
Product Name:Bromfenac-d4 (sodium salt)
CAS:2749400-35-7
Purity:Purity: >=98% Package:1mg Remarks:CA26598
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:Bromfenac-d4 (sodium salt)
CAS:2749400-35-7
Purity:95% Package:500μg;1mg
|
| Company Name: |
Cayman Chemical Company
|
| Tel: |
800-364-9897 |
| Email: |
sales@caymanchem.com |
| Products Intro: |
Product Name:Bromfenac-d4 (sodium salt)
CAS:2749400-35-7
|
| Company Name: |
Cayman Chemical Company
|
| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:Bromfenac-d4 (sodium salt)
CAS:2749400-35-7
|
|
| | 2-amino-3-(4-bromobenzoyl-2,3,5,6-d4)-benzeneaceticacid,monosodiumsalt Basic information |
| | 2-amino-3-(4-bromobenzoyl-2,3,5,6-d4)-benzeneaceticacid,monosodiumsalt Chemical Properties |
| solubility | DMSO: 100 mM; Ethanol: 5 mM; Water: 100 mM | | form | A solid |
| | 2-amino-3-(4-bromobenzoyl-2,3,5,6-d4)-benzeneaceticacid,monosodiumsalt Usage And Synthesis |
| Description | Bromfenac-d4 is intended for use as an internal standard for the quantification of bromfenac by GC- or LC-MS. Bromfenac is an inhibitor of cyclooxygenase 2 (COX-2; IC50 = 6.6 nM) that is selective over COX-1 (IC50 = 210 nM).1 It inhibits prostaglandin E2 (PGE2; ） production in a rabbit model of LPS-induced eye inflammation. Bromfenac also decreases inflammation following cataract removal in dogs when administered as a 0.9% topical solution on a tapering schedule for 24 weeks.2 Formulations containing bromfenac have been used in the treatment of postoperative inflammation following cataract surgery. | | Uses | Bromfenac-d4 (sodium) is deuterium labeled Bromfenac (sodium). Bromfenac sodium is a potent and orally active inhibitor of COX, with IC50s of 5.56 and 7.45 nM for COX-1 and COX-2, respectively. Bromfenac sodium is a brominated non-steroidal anti-inflammatory/analgesic agent (NSAID), and it is commonly used for the research of postoperative inflammation and pain following cataract surgery, and pseudophakic cystoid macular edema (CME)[1][2]. | | References | 1. Waterbury, L.D., Silliman, D., and Jolas, T. Comparison of cyclooxygenase inhibitory activity and ocular anti-inflammatory effects of ketorolac tromethamine and bromfenac sodium Curr. Med. Res. Opin. 22(6),1133-1140(2006).
2. Brookshire, H.L., English, R.V., Nadelstein, B., et al. Efficacy of COX-2 inhibitors in controlling inflammation and capsular opacification after phacoemulsification cataract removal Vet. Ophthalmol. 18(3),175-185(2015). |
| | 2-amino-3-(4-bromobenzoyl-2,3,5,6-d4)-benzeneaceticacid,monosodiumsalt Preparation Products And Raw materials |
|