| Company Name: |
ShangHai Biochempartner Co.,Ltd
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| Tel: |
17754423994 17754423994 |
| Email: |
2853530910@QQ.com |
| Products Intro: |
Product Name:Dup-721
CAS:104421-21-8
Purity:98% HPLC LCMS Package:100MG;1G
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| | 4-acetylphenyloxooxazolidinylmethylacetamide Basic information |
| Product Name: | 4-acetylphenyloxooxazolidinylmethylacetamide | | Synonyms: | 4-acetylphenyloxooxazolidinylmethylacetamide;DuP-721;N-[[(5S)-2-Oxo-3-(4-acetylphenyl)-5α-oxazolidinyl]methyl]acetamide;N-[[(5S)-3-(4-Acetylphenyl)-2-oxooxazolidin-5-yl]methyl]acetamide;N-[[(5S)-3-(4-Acetylphenyl)-2-oxooxazolidin-5α-yl]methyl]acetamide;Dup-721,M. tuberculosis,anti-tuberculosis,Mycobacterium tuberculosis,Inhibitor,M. intracellulare,inhibit,M. kansassi,Dup 721,Dup721,Antibiotic,Bacterial | | CAS: | 104421-21-8 | | MF: | C14H16N2O4 | | MW: | 276.29 | | EINECS: | | | Product Categories: | | | Mol File: | 104421-21-8.mol |  |
| | 4-acetylphenyloxooxazolidinylmethylacetamide Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO:100.0(Max Conc. mg/mL);361.94(Max Conc. mM) |
| | 4-acetylphenyloxooxazolidinylmethylacetamide Usage And Synthesis |
| Biological Activity | DuP-721 is a broad spectrum and orally active antibacterial agent against a variety of clinically susceptible and resistant bacteria, especially M. tuberculosis[1].
DuP-721 (1.5-4 μg/ml) inhibits equally the strains of Mycobacterium tuberculosis susceptible and resistant to conventional antituberculosis drug. And it does not show cross resistance to any of the anti-tuberculosis drugs tested[1].DuP-721 is inactive against M. avium and M. intracellulare at 250 μg/ml. It inhibits M. gordonoe and M. fortuitum at 3.9 μg/ml and M. kansassi and M. scrofulaceum at 1.95 μg/ml and 15.6 μg/ml, respectively[1].
DuP-721 (oral gavage; 50-160 mg/kg) is protective against M. tuberculosis infection in mice. DuP-721 protects 100% of the infected animals at 50 mg/kg p.o. dose when administered daily for 17 days, and the same effect is observed at 160 mg/kg dose when the drug is administered only on day 11 and 12 post infection[1]. | | References | [1]. Affiliatio, et al. Antimycobacterial activities of oxazolidinones: a review. Infect Disord Drug Targets. 2006 Dec;6(4):343-54. |
| | 4-acetylphenyloxooxazolidinylmethylacetamide Preparation Products And Raw materials |
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