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| | 1-Isoquinolinecarbonitrile Basic information |
| | 1-Isoquinolinecarbonitrile Chemical Properties |
| Melting point | 90-92 °C (lit.) | | Boiling point | 348.9±15.0 °C(Predicted) | | density | 1.21±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | -0.48±0.30(Predicted) | | Water Solubility | Insoluble in water. | | BRN | 119104 | | CAS DataBase Reference | 1198-30-7(CAS DataBase Reference) |
| Hazard Codes | Xn,Xi | | Risk Statements | 20/21/22-36/37/38 | | Safety Statements | 26-37/39 | | RIDADR | 3276 | | WGK Germany | 3 | | Hazard Note | Irritant | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 2933499090 |
| | 1-Isoquinolinecarbonitrile Usage And Synthesis |
| Uses | 1-Isoquinolinecarbonitrile may be used as starting reagent in the syntheses of imidazo[5,1-a]isoquinolines. | | Preparation | Phosphoryl chloride (0.54 g, 3.5 mmol) in chloroform (5 mL) was added dropwise to a solution of the requisite carbaldoxime (0.2 g, 1.2 mmol) in chloroform (10 mL) under ice-cooling. The mixture was heated under reflux for 4 h, treated with iced water, and the resulting precipitate was filtered off. The filtrate was basified with 28% ammonia and then extracted with chloroform to give 1-cyanoisoquinoline 1440; yield 0.17 g (95%). | | Synthesis Reference(s) | The Journal of Organic Chemistry, 49, p. 4056, 1984 DOI: 10.1021/jo00195a036
Tetrahedron Letters, 19, p. 589, 1978 | | General Description | Effect of magnetic field on the photosubstitution reaction of 1-isoquinolinecarbonitrile in ethanol has been reported. Conjugated polynitrile, plasma-polymerized 1-isoquinolinecarbonitrile (PPIQCN) has been prepared by plasma polymerization. |
| | 1-Isoquinolinecarbonitrile Preparation Products And Raw materials |
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