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| | N-NITROSOMORPHOLINE Basic information |
| | N-NITROSOMORPHOLINE Chemical Properties |
| Melting point | 29°C | | Boiling point | 225℃ | | density | 1.2829 (rough estimate) | | refractive index | 1.4880 (estimate) | | Fp | 29 °C | | storage temp. | 2-8°C | | Water Solubility | Completely soluble in water | | solubility | DMSO : 100 mg/mL (861.18 mM) | | pka | -5.72±0.20(Predicted) | | color | White or Colorless to Yellow | | Merck | 14,6640 | | Stability: | Stable, but light-sensitive. Combustible. Incompatible with strong oxidizing agents. Refrigerate, store in the dark. | | IARC | 2B (Vol. 17, Sup 7) 1987 | | EPA Substance Registry System | N-Nitrosomorpholine (59-89-2) |
| | N-NITROSOMORPHOLINE Usage And Synthesis |
| Chemical Properties | yellow crystals or gold liquid | | Uses | N-Nitrosomorpholine, a frequently used genotoxic model carcinogen. Toxicogenomic analysis of N-Nitrosomorpholine induced changes in rat liver. | | Uses | Solvent for polyacrylonitrile; present
during rubber manufacturing | | Definition | ChEBI: A nitrosamine that is morpholine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. A carcinogen and mutagen, it is found in snuff tobacco. | | Synthesis Reference(s) | Synthetic Communications, 22, p. 2607, 1992 DOI: 10.1080/00397919208021659 | | General Description | Yellow crystals. Golden liquid with many crystals at 68°F. | | Air & Water Reactions | Water soluble. | | Reactivity Profile | N-NITROSOMORPHOLINE is incompatible with strong oxidizing agents . | | Health Hazard | ACUTE/CHRONIC HAZARDS: When heated to decomposition N-NITROSOMORPHOLINE emits toxic fumes of nitrogen oxides. | | Fire Hazard | Flash point data for N-NITROSOMORPHOLINE are not available; however, N-NITROSOMORPHOLINE is probably combustible. | | Biochem/physiol Actions | Tumor initiator in rodent liver, trachea, nasal cavity, esophagus, kidney, lung, and thyroid. | | Safety Profile | Confirmed carcinogen
with experimental carcinogenic,
neoplastigenic, and tumorigenic data. Poison
by ingestion, intraperitoneal, subcutaneous,
and intravenous routes. Moderately toxic by
inhalation. Human mutation data reported.
Experimental reproductive effects. When
heated to decomposition it emits toxic
fumes of NOx. See also N-NITROSO
COMPOUNDS. | | Carcinogenicity | N-Nitrosomorpholine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals. |
| | N-NITROSOMORPHOLINE Preparation Products And Raw materials |
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