- Ziconotide acetate
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- $0.00 / 20kg
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2024-05-06
- CAS:107452-89-1
- Min. Order: 20kg
- Purity: 99%
- Supply Ability: 200000
- Ziconotide Polyacetate
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- $8.00 / 1KG
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2024-03-29
- CAS:107452-89-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
- ω-Conotoxin MVIIA
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- $10.00 / 1kg
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2024-03-08
- CAS:107452-89-1
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 1000kg
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| | Ziconotide Polyacetate Basic information |
| Product Name: | Ziconotide Polyacetate | | Synonyms: | OMEGA-CONOTOXIN MVIIA;OMEGA-CGTX MVII A;ZICONOTIDE ACETATE;snx111;H-CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2;H-CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2 (DISULFIDE BRIDGE: 1-16, 8-20, AND 15-25);CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2;CKGKGAKCSRLMYDCCTGSCRSGKC-NH2 (DISULFIDE BRIDGE: 1-16,8-20, AND 15-25) | | CAS: | 107452-89-1 | | MF: | C102H172N36O32S7 | | MW: | 2639.13 | | EINECS: | | | Product Categories: | Peptide;107452-89-1 | | Mol File: | 107452-89-1.mol |  |
| | Ziconotide Polyacetate Chemical Properties |
| density | 1.60±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO (Slightly, Sonicated), Methanol (Slightly) | | form | Solid | | color | White to Off-White | | InChIKey | BPKIMPVREBSLAJ-QTBYCLKRSA-N |
| | Ziconotide Polyacetate Usage And Synthesis |
| Description | ω-conotoxin MVIIA, also knwn as Ziconotide acetate, is a peptide consisting of 25 amino acid. It is a disulfide-bridged polypeptide from the venom of the sea snail Conusmagus that binds to neuronal N-type calcium channels. It forms a compact folded structure, presenting a loop between Cys8 and Cys15 that contains a set of residues critical for its binding. Both ω-conotoxins GVIA and MVIIA could bind to neuronal N-type calcium channels. ω-conotoxin GVIA is rich in hydroxyl groups while ω-conotoxin MVIIA contains a large number of positively charged side chains[1-2]. | | Uses | Ziconotide acetate (ω-Conotoxin MVIIA), the peptide toxin of the Conus magus (cone snail) is a selective antagonist of N-type voltage sensitive calcium channels (VSCC). As a most well-known identified conotoxin so far, it has been used as a effective drug to treat intractable chronic pain in cancer and ADIS patients[2]. Blocks neurotransmitter release by preventing depolarization-induced calcium influx. Used as a ligand for binding studies of voltage sensitive calcium channels. Analgesic; neuroprotective. | | Brand name | Prialt (Elan). | | General Description | ω-Conotoxin MVIIA functions as a selective inhibitor of N-type voltage-sensitive calcium channels (VSCCs). It has analgesic and neuroprotective effects. ω-Conotoxin MVIIA is used to treat neuropathic pain. | | Biochem/physiol Actions | Neuronal N-type Ca2+ channel blocker in mammalian and amphibian brain; blocks release of GABA and glutamate at neuronal synapses. | | References | [1] Wang R, et al. Development of an ic-ELISA and immunochromatographic strip based on IgG antibody for detection of ω-conotoxin MVIIA. Journal of Hazardous Materials, 2019; 378: 120510.
[2] Zhou Y, et al. A Chemoenzymatic Approach To Produce a Cyclic Analogue of the Analgesic Drug MVIIA (Ziconotide). Angew. Chem. Int. Ed., 2023; 62: e202302812. |
| | Ziconotide Polyacetate Preparation Products And Raw materials |
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