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CITRININ

CITRININ Suppliers list
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512
Email: info@tianfuchem.com
Products Intro: Product Name:TIANFUCHEM--High purity CITRININ factory price
CAS:518-75-2
Purity:99% Package:25KG;5KG;1KG
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: 21-51619050
Email: ivan@atkchemical.com
Products Intro: CAS:518-75-2
Company Name: Shanghai Standard Technology Co., Ltd.
Tel: 18502101150
Email: ft-sales@nature-standard.com
Products Intro: Product Name:Citrinin
CAS:518-75-2
Purity:>=98%(HPLC) Package:5mg;USD
Company Name: career henan chemical co
Tel: +86-0371-86658258
Email: factory@coreychem.com
Products Intro: Product Name:CITRININ
CAS:518-75-2
Purity:>98% HPLC Package:1KG;8USD
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel: +86-029-87569262 +8615319740599
Email: 1007@dideu.com
Products Intro: Product Name:CITRININ
CAS:518-75-2
Purity:99% Package:1KG;1USD

CITRININ manufacturers

  • Citrinin
  • $0.00 / 1KG
  • 2023-02-02
  • CAS:518-75-2
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 500000kg
  • CITRININ USP/EP/BP
  • $1.10 / 1g
  • 2021-06-24
  • CAS:518-75-2
  • Min. Order: 1g
  • Purity: 99.9%
  • Supply Ability: 100 Tons Min
  • Citrinin
  • $0.00 / 5mg
  • 2020-05-11
  • CAS:518-75-2
  • Min. Order: 5mg
  • Purity: ≥98%(HPLC)
  • Supply Ability: 10 g
CITRININ Basic information
Product Name:CITRININ
Synonyms:CITRININ;CITRININ, PENICILLIUM CITRINUM;4,6-DIHYDRO-8-HYDROXY-3,4,5-TRIMETHYL-6-OXO-3H-2-BENZOPYRAN-7-CARBOXYLIC;4,6-DIHYDRO-8-HYDROXY-3,4,5-TRIMETHYL-6-OXO-3H-2-BENZOPYRAN-7-CARBOXYLIC ACID;(3r,4s)-4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3h-2-benzopyran-7-carbox;3H-2-Benzopyran-7-carboxylic acid, 4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-, (3R,4S)-;CITRININE;Antimycin, Citrinin
CAS:518-75-2
MF:C13H14O5
MW:250.25
EINECS:208-257-2
Product Categories:antibiotic;Chiral Reagents;Active Pharmaceutical Ingredients;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:518-75-2.mol
CITRININ Structure
CITRININ Chemical Properties
Melting point 175°C (dec.)
alpha D18 -37.4° (c = 1.15 in alc.)
Boiling point 313.38°C (rough estimate)
density 1.37
refractive index 1.4560 (estimate)
Fp 2℃
storage temp. 2-8°C
solubility ≤2mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
pka1.52±0.60(Predicted)
form Crystalline Powder or Flakes
color Yellow
Merck 13,2351
BRN 5282243
CAS DataBase Reference518-75-2(CAS DataBase Reference)
IARC3 (Vol. 40, Sup 7) 1987
EPA Substance Registry SystemCitrinin (518-75-2)
Safety Information
Hazard Codes T
Risk Statements 23/24/25-40-36/37/38
Safety Statements 26-36/37/39-45-22-7/9
RIDADR UN 3462 6.1/PG 3
WGK Germany 3
RTECS DJ2275000
HazardClass 6.1(a)
PackingGroup II
HS Code 29419090
Hazardous Substances Data518-75-2(Hazardous Substances Data)
ToxicityLD50 in mice, rats (mg/kg): 35, 67 i.p. (Ambrose, De Eds)
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
CITRININ Usage And Synthesis
DescriptionCitrinin is a mycotoxin that has been found in Monascus and has diverse biological activities. It is active against S. aureus, methicillin-resistant S. aureus (MRSA), rifampicin-resistant S. aureus, and vancomycin-resistant E. faecium (MICs = 1.95, 3.9, 0.97, and 7.81 μg/ml, respectively), as well as the pathogenic yeast C. neoformans (MIC = 3.9 μg/ml). It is cytotoxic to a variety of cells in vitro, including bovine kidney cells and mice embryonic stem cells. Citrinin (30 μM) induces reactive oxygen species (ROS) production, mitochondrial membrane potential loss, and apoptosis in HepG2 cells, effects that can be blocked by the antioxidant resveratrol. In contrast, citrinin reduces glutamate-induced excitotoxicity in primary rat cortical neurons at concentrations ranging from 0.1 to 1,000 nM and inhibits LPS-induced production of nitric oxide (NO) in RAW 264.7 cells at 0.625 to 40 μM. It is toxic to brine shrimp larvae (LD50 = 96 μg/ml), as well as to rats and mice with oral LD50 values of 50 and 87-105 mg/kg, respectively. It induces reproductive abnormalities in male mice and toxic effects in the liver, kidney, heart, and gastrointestinal tracts of various animals. Citrinin has been found in stored cereal grains, as well as beans, fruit, and herbs.
Chemical Propertiesyellow crystalline powder or flakes
Chemical PropertiesAntimycin (A3C26H36N2O9) and (Antimycin A1) C28H40N2O9 are crystalline solids.
Usesantibacterial
UsesAntibiotic substance produced by a white spore aspergilus which has been placed under the species name Aspergillus niveus. Also produced in small quantities by Penicillium citrinum.
UsesCitrinin is a quinonemethine mycotoxin produced by diverse fungi including Aspergillus and Penicillium. Citrinin has been extensively investigate, and is a potent nephrotoxin with hepatoxic and teratogenic activity. Citrinin is the causative agent of Balkan nephropathy and yellow rice fever in humans. At the molecular level, citrinin exhibits a range of effects including free radical damage to DNA and disruption of mitochondrial membrane-bound enzymic activities and structural integrity. Specifically, citrinin is an inhibitor of NADH dehydrogenase in the mitochondrial electron transport chain and this action is responsible for recent reports of citrinin's apoptotic activity.
General DescriptionCitrinin is a hepato-nephrotoxic mycotoxin. It can be produced by several filamentous fungi genera of Monauscus, Aspergillus, and Penicillium, which is commonly found as a contaminant in stored grains, foods, feedstuffs and also in biological fluids.
Potential ExposureSpecific uses for antimycin A were not found, however, antimycin A1, and antimycin A3 are reported to be antibiotic substances produced by streptomyces for use as a fungicide, possible insecticide and miticide. Registered as a pesticide in the U.S.
in vitroprevious study found that exposure of hek293 cells to citrinin led to an arrest of cell cycle g2/m in a concentration-dependent increase. citrinin treatment could also elevate the expression levels of p53 and p21 proteins, yet attenuate the signals of phosphorylated cell division cycle 2. moreover, treating hek293 with citrinin could increase both the value of mitotic index and the population of cells, indicating that arrest of citrinin -induced cell cycle occurred mainly during the mitotic phase [1].
in vivoprevious study showed that citrinin acted as a nephrotoxin in all tested animal species, but its acute toxicity varied in different species. the 50% lethal dose for ducks is 57 mg/kg; for chickens it is 95 mg/kg; and for rabbits it is 134 mg/kg. in murine kidneys, citrinin could also synergistically act with ochratoxin a to depress rna synthesis [2].
ShippingUN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
references[1] chang ch, yu fy, wu ts, wang lt, liu bh. mycotoxin citrinin induced cell cycle g2/m arrest and numerical chromosomal aberration associated with disruption of microtubule formation in human cells. toxicol sci. 2011 jan;119(1):84-92.
[2] j. w. bennett and m. klich. mycotoxins. clin.microbiol.rev. 16(3), 497-516 (2003).
CITRININ Preparation Products And Raw materials
Tag:CITRININ(518-75-2) Related Product Information
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