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Liothyronine sodium

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Company Name: Suzhou Ryan Pharmachem Technology Co.,Ltd.
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Products Intro: Product Name:Liothyronine sodium
CAS:55-06-1
Purity:98% Package:G;KG Remarks:RA-40005
Company Name: Henan DaKen Chemical CO.,LTD.
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CAS:55-06-1
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
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CAS:55-06-1
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Company Name: Hangzhou FandaChem Co.,Ltd.
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Products Intro: Product Name:Liothyronine Sodium
CAS:55-06-1
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Company Name: Nanjing ChemLin Chemical Industry Co., Ltd.
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Products Intro: CAS:55-06-1
Purity:95-101% Package:g-Kg Remarks:Yellow brown powder

Lastest Price from Liothyronine sodium manufacturers

  • Liothyronine sodium
  • US $0.00 / KG
  • 2021-08-04
  • CAS:
  • Min. Order: 100g
  • Purity: 98%+
  • Supply Ability: 100kg
  • Liothyronine sodium
  • US $0.00 / KG
  • 2021-08-04
  • CAS:55-06-1
  • Min. Order: 100g
  • Purity: 98%+
  • Supply Ability: 100kg
Liothyronine sodium Basic information
Product Name:Liothyronine sodium
Synonyms:LIOTHYRONINESODIUM,USP;3,3',5-Triiodothyronine sodium salt;3,5,3'-Triiodo-L-thyronine monosodium salt;Alanine, 3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-, monosodium salt, L- (8CI);Basoprocin;Cynomel;Cyomel;Cytobin
CAS:55-06-1
MF:C15H11I3NNaO4
MW:672.96
EINECS:200-223-5
Product Categories:Other APIs;Isolabel;Amino Acids & Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals;Steroid and Hormone
Mol File:55-06-1.mol
Liothyronine sodium Structure
Liothyronine sodium Chemical Properties
Melting point 205 °C (dec.)(lit.)
alpha 20 º (c=2,alcohol/1.2N HCl)
RTECS YP2836500
storage temp. 2-8°C
solubility 4 M NH4OH in methanol: 125 g/5mL, clear, yellow-brown
form powder
color White to Pale Brown
Water Solubility Partly miscible in water. Soluble in dimethyl sulfoxide, methanol, sodium hydroxide and ethanol. Practically insoluble in most other organic solvents.
Sensitive Light Sensitive
Merck 5510
BRN 8179867
CAS DataBase Reference55-06-1(CAS DataBase Reference)
EPA Substance Registry SystemL-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-, monosodium salt (55-06-1)
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22
Safety Statements 22-24/25-36
WGK Germany 3
3-8-10
HS Code 29379000
Liothyronine sodium Usage And Synthesis
Chemical Propertieswhite to beige powder
OriginatorCytomel,SKF,US,1956
UsesOne of the hormones produced by the thyroid gland that is involved in the maintenance of metabolic homeostasis. Also produced in peripheral tissues as the active metabolite of Thyroxine.
Usescytochrome P450 inhibitor, Ca antagonist, anesthetic (local)
DefinitionChEBI: The sodium salt of liothyronine. Thought to be more active than levothyroxine and with a rapid (few hours) onset and short duration of action, liothyronine sodium is used in the treatment of hypothyroidism, particularly in cases of hypothyroid coma.
IndicationsLiothyronine sodium (Cytomel) is the sodium salt of the naturally occurring levorotatory isomer of T3. Liothyronine is generally not used for maintenance thyroid hormone replacement therapy because of its short plasma half-life and duration of action. The use of T3 alone is recommended only in special situations, such as in the initial therapy of myxedema and myxedema coma and the short-term suppression of TSH in patients undergoing surgery for thyroid cancer. The use of T3 alone may also be useful in patients with the rare condition of 5'-deiodinase deficiency who cannot convert T4 to T3.
Manufacturing ProcessThe 3,5-diiodo compound used as a starting material is a known material and may be prepared by the method in British Patents 643,089 and 671,070 and in the Journal of the Chemical Society, London, 1949, page 3424.
Synthesis: L-diiodo thyronine (1.05 g) is dissolved in ammonia (specific gravity 0.880) (40 ml) and methanol (40 ml) and iodinated slowly with shaking with N-iodine in KI solution at room temperature. After iodination,most of the ammonia and methanol are removed by evaporation under diminished pressure, water is added to the original volume, the solution is heated to 60°C and brought to pH 4 with hydrochloric acid. A crystalline precipitate is obtained which after cooling to room temperature is collected and washed with water. At this stage, the crude triiodo thyronine is contaminated with thyroxine and a little unchanged diiodo thyronine.
Purification: The crude precipitate is dissolved in boiling 2N HCl (300 ml) and filtered from the relatively insoluble thyroxine hydrochloride. The hot filtrate is brought to pH 4 with 5N NaOH and triiodo thyronine again separates; after chilling at 0° to 4°C it is collected, washed with water and dried. The yield of triiodo thyronine is 70 to 75% of the theoretical. This triiodo thyronine still contains some thyroxine (about 10%).
The final purification consists of chromatographic separation of thyroxine and triiodo thyronine on a kieselguhr column using 20% chloroform in n-butanol equilibrated with 0.5N NaOH as the developing solvent. 80 to 100 mg triiodo thyronine is purified during each run on a 50 g kieselguhr column. Pure Ltriiodo thyronine has MP 236° to 237°C (dec.) and [α]D29.5° = +21.5 in a 4.75% solution in a mixture of 1 part of N HCl and 2 parts of ethanol. Liothyronine is commonly used as the sodium salt.
Brand nameThyroid hormone Cytomel (King); Triostat (Jones).
Therapeutic FunctionThyroid hormone
Veterinary Drugs and TreatmentsBecause of its shorter duration of action, liothyronine is generally not considered the drug of first choice in treating hypothyroidism. Infrequently, animals not responding to levothyroxine may respond to liothyronine.
Liothyronine sodium Preparation Products And Raw materials
Raw materials3,5-Diiodo-L-thyronine-->iodine
Tag:Liothyronine sodium(55-06-1) Related Product Information
O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine Trisodium phosphate Sodium chloride Sodium periodate Sodium levothyroxine Sodium bicarbonate Sodium iodate Sodium alginate Sodium citrate TSH REVERSE T3 Diclofenac sodium CHLOROPHOSPHONAZO III Sodium benzoate MCPA SODIUM Inositol sodium Liothyronine sodium