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Acesulfame potassium

Acesulfame potassium Suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Products Intro: Product Name:6-Methyl-1,2,3-oxathiazin-4(3H)-one 2,2-dioxide potassium salt
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Products Intro: Product Name:55589-62-3
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: Shanghai Yingrui Biopharma Co., Ltd.
Tel: +86-21-33585366
Products Intro: Product Name:Acesulfame Potassium
Purity:99% Package:100g;500g;1kg;25kg...
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: 86-0551-65418684 18949823763
Products Intro: Product Name:Acesulfame
Purity:USP BP EP Package:1ASSAYS;1USD
Company Name: Hebei Chisure Biotechnology Co., Ltd.
Tel: +8613292890173
Products Intro: Product Name:Acesulfame K
Purity:99% Package:1ASSAYS;10USD

Lastest Price from Acesulfame potassium manufacturers

  • AcesulfaMe K
  • US $0.01-1.00 / KG
  • 2020-04-22
  • CAS:55589-62-3
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 50 tons
Acesulfame potassium Basic information
Product Name:Acesulfame potassium
Synonyms:acesulfame;ACESULFAME POTASSIUM;Ak Candy;AcesuL;fame potassium [NF];Acessulfame-K;1,2,3-oxathiazin-4(3h)-one,6-methyl-,2,2-dioxide,potassiumsalt;6-methyl-3,4-dihydro-1,2,3-oxathiazin-4-one2,2-dioxidepotassiumsalt
Product Categories:SUNETT;Food & Feed ADDITIVES;K (Potassium) Compounds (excluding simple potassium salts);Classes of Metal Compounds;Typical Metal Compounds;Sweeteners;Food & Flavor Additives;Heterocycles;Sulfur & Selenium Compounds
Mol File:55589-62-3.mol
Acesulfame potassium Structure
Acesulfame potassium Chemical Properties
Melting point 229-232°C (dec.)
density (solid) 1.81 g/cm3; d (bulk) 1.1-1.3 kg/dm3
storage temp. 0-6°C
solubility Soluble in water, very slightly soluble in acetone and in ethanol (96 per cent).
form neat
color White crystalline solid
Odorodorless with sweet taste
Water Solubility almost transparency
Merck 14,37
BRN 3637857
CAS DataBase Reference55589-62-3(CAS DataBase Reference)
EPA Substance Registry SystemAcesulfame-potassium (55589-62-3)
Safety Information
Risk Statements 36/37/38
Safety Statements 26-36/37/39
WGK Germany 1
RTECS RP4489165
HS Code 2934990002
ToxicityLD50 in rats (mg/kg): 7431 orally, 2243 i.p. (Mayer, Kemper)
MSDS Information
SigmaAldrich English
Acesulfame potassium Usage And Synthesis
Chemical PropertiesWhite to Off-White Solid
Chemical PropertiesAcesulfame potassium occurs as a colorless to white-colored, odorless, crystalline powder with an intensely sweet taste.
HistoryAcesulfame-K, the potassium salt of acesulfame, is a sweetener that resembles saccharin in structure and taste profile. 5,6-Dimethyl-1,2,3-oxathiazine-4(3H)-one 2,2-dioxide, the first of many sweet compounds belonging to the dihydrooxathiazinone dioxide class, was discovered accidentally in 1967. From these many sweet compounds, acesulfame was chosen for commercialization. To improve water solubility, the potassium salt was made. Acesulfame-K (Sunett) was approved for dry product use in the United States in 1988 and in Canada in October, 1994. In 2003, acesulfame-K was approved as a general purposes sweetener by the FDA.
UsesPotassium salt as sweetener for foods, cosmetics.
Uses'New generation', heat-stable sweetener that has not been suspected to cause cancer nor be genotoxic. Allelic variation of the Tas1r3 gene affects behavioral taste responses to this molecule, suggesting that it is a T1R3 receptor ligand.
UsesAcesulfame-K is the potassium salt of 6-methyl-l,2,3-oxathiazin-4(3H)- one-2,2-dioxide. This sweetener was discovered in Germany and was first approved by the FDA in 1988 for use as a nonnutritive sweetener. The complex chemical name of this substance led to the creation of the trademark common name, acesulfame-K, which is based on its following relationships to acetocetic acid and sulfanic acid, and to its potassium salt nature.
Acesulfame-K is 200 times as sweet as sugar and is not metabolized and is thus noncaloric. It is exceptionally stable at elevated temperatures encountered in baking, and it is also stable in acidic products, such as carbonated soft drinks. It has a synergistic effect when mixed with other low-calorie sweetners, such as aspartame. Common applications of acesulfame-K are table uses, chewing gums, beverages, foods, bakery products, confectionary, oral hygiene products, and pharmaceuticals.
Production MethodsAcesulfame potassium is synthesized from acetoacetic acid tertbutyl ester and fluorosulfonyl isocyanate. The resulting compound is transformed to fluorosulfonyl acetoacetic acid amide, which is then cyclized in the presence of potassium hydroxide to form the oxathiazinone dioxide ring system. Because of the strong acidity of this compound, the potassium salt is produced directly.
An alternative synthesis route for acesulfame potassium starts with the reaction between diketene and amidosulfonic acid. In the presence of dehydrating agents, and after neutralization with potassium hydroxide, acesulfame potassium is formed.
Production MethodsThe principal commercial process for acesulfame-K is depicted below: 图
Pharmaceutical ApplicationsAcesulfame potassium is used as an intense sweetening agent in cosmetics, foods, beverage products, table-top sweeteners, vitamin and pharmaceutical preparations, including powder mixes, tablets, and liquid products. It is widely used as a sugar substitute in compounded formulations,and as a toothpaste sweetener.
The approximate sweetening power is 180–200 times that of sucrose, similar to aspartame, about one-third as sweet as sucralose, one-half as sweet as sodium saccharin, and about 4-5 times sweeter than sodium cyclamate.It enhances flavor systems and can be used to mask some unpleasant taste characteristics.
Safety ProfileWhen heated to decompositionemits toxic fumes of SOx.
SafetyAcesulfame potassium is widely used in beverages, cosmetics, foods, and pharmaceutical formulations, and is generally regarded as a relatively nontoxic and nonirritant material. Pharmacokinetic studies have shown that acesulfame potassium is not metabolized and is rapidly excreted unchanged in the urine. Long-term feeding studies in rats and dogs showed no evidence to suggest acesulfame potassium is mutagenic or carcinogenic.
The WHO has set an acceptable daily intake for acesulfame potassium of up to 15 mg/kg body-weight.The Scientific Committee for Foods of the European Union has set a daily intake value of up to 9 mg/kg of body-weight.
LD50 (rat, IP): 2.2 g/kg
LD50 (rat, oral): 6.9–8.0 g/kg
storageAcesulfame potassium possesses good stability. In the bulk form it shows no sign of decomposition at ambient temperature over many years. In aqueous solutions (pH 3.0–3.5 at 208℃) no reduction in sweetness was observed over a period of approximately 2 years. Stability at elevated temperatures is good, although some decomposition was noted following storage at 408℃ for several months. Sterilization and pasteurization do not affect the taste of acesulfame potassium.
The bulk material should be stored in a well-closed container in a cool, dry place and protected from light.
Regulatory StatusIncluded in the FDA Inactive Ingredients Database for oral and sublingual preparations. Included in the Canadian List of Acceptable Non-medicinal Ingredients. Accepted for use in Europe as a food additive. It is also accepted for use in certain food products in the USA and several countries in Central and South America, the Middle East, Africa, Asia, and Australia.
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