- 3-Thiophenecarbonitrile
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- $1786.00 / 1Kg
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2024-11-12
- CAS:1641-09-4
- Min. Order: 1Kg
- Purity: 99 %
- Supply Ability: 1000 Kg
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| | 3-Thiophenecarbonitrile Basic information |
| | 3-Thiophenecarbonitrile Chemical Properties |
| Boiling point | 82 °C10 mm Hg(lit.) | | density | 1.2 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.5630(lit.) | | Fp | 186 °F | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | form | Liquid | | Specific Gravity | 1.2 | | color | Clear colorless | | BRN | 107104 | | InChI | 1S/C5H3NS/c6-3-5-1-2-7-4-5/h1-2,4H | | InChIKey | GSXCEVHRIVLFJV-UHFFFAOYSA-N | | SMILES | N#Cc1ccsc1 | | CAS DataBase Reference | 1641-09-4(CAS DataBase Reference) |
| Hazard Codes | Xn,Xi | | Risk Statements | 20/21/22-36/37/38 | | Safety Statements | 26-36-36/37 | | RIDADR | 3276 | | WGK Germany | 3 | | Hazard Note | Harmful | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29341000 | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 3-Thiophenecarbonitrile Usage And Synthesis |
| Chemical Properties | Clear colorless liquid | | Uses | 3-Thiophenecarbonitrile can be used to synthesize the following:
- 2,4-dinaphthyl-3-cyanothiophene via reaction with iodonaphthalene
- 2,5-bis-tri(n-butyl)tin-3-cyanothiophene, a building block for the synthesis of new alternating (3-alkyl/3-cyano)thiophene copolymers
| | Synthesis Reference(s) | The Journal of Organic Chemistry, 44, p. 1670, 1979 DOI: 10.1021/jo01324a019
Synthetic Communications, 20, p. 3153, 1990 DOI: 10.1080/00397919008051539 | | Synthesis | General procedure for the synthesis of 3-cyanothiophene from 3-thiophenecarboxaldehyde: A mixture of 3-thiophenecarboxaldehyde (1.0 mmol), NH2OH-HCl (1.5 mmol), and Cog-C3N4 (20 mg) in H2O/MeOH (1:1, 5 mL) was added to a round-bottomed flask and the reaction was stirred for 14-20 h at room temperature under visible-light irradiation. The reaction progress was monitored by TLC. After completion of the reaction, the catalyst was removed by filtration and the filtrate was extracted by adding EtOAc (10 mL) to the filtrate. The organic layer was separated and washed sequentially with brine (2 x 5 mL) and distilled water (1 x 10 mL) and then dried with anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give the crude product. The crude product was further purified by fast column chromatography with the eluent ratio of EtOAc/hexane (10:90) to obtain analytically pure 3-cyanothiophene. | | References | [1] Organic Letters, 2017, vol. 19, # 11, p. 3005 - 3008
[2] Catalysis Communications, 2019, p. 76 - 81
[3] Journal of Polymer Science, Part A: Polymer Chemistry, 2014, vol. 52, # 8, p. 1055 - 1058
[4] Tetrahedron Letters, 2012, vol. 53, # 7, p. 882 - 885
[5] Chemical Communications, 2013, vol. 49, # 54, p. 6030 - 6032 |
| | 3-Thiophenecarbonitrile Preparation Products And Raw materials |
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