Retaspimycin Hydrochloride manufacturers
- Retaspimycin Hydrochloride
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- $15.00 / 1KG
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2021-07-13
- CAS:857402-63-2
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- Retaspimycin Hydrochloride
-
- $15.00 / 1KG
-
2021-07-09
- CAS:857402-63-2
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| | Retaspimycin Hydrochloride Basic information |
| Product Name: | Retaspimycin Hydrochloride | | Synonyms: | 17-Allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride;Ipi 504;Ipi-504;Unii-928Q33Q049;18,21-Didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-17-(2-propen-1-ylamino)geldanamycin hydrochloride;Retaspimycin hydrochloride;IPI-504 (RetaspiMycin hydrochloride);IPI-504 (Retaspimycin HCl) | | CAS: | 857402-63-2 | | MF: | C31H47N3O8.ClH | | MW: | 626.186 | | EINECS: | 200-258-5 | | Product Categories: | | | Mol File: | 857402-63-2.mol |  |
| | Retaspimycin Hydrochloride Chemical Properties |
| storage temp. | Store at -20°C | | solubility | ≥26.1 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥100 mg/mL in EtOH with ultrasonic | | form | solid |
| | Retaspimycin Hydrochloride Usage And Synthesis |
| Definition | ChEBI: A hydrochloride that is the monohydrochloride salt of retaspimycin. A semi-synthetic water-soluble analogue of geldanamycin used in cancer treatment. | | Biological Activity | retaspimycin hydrochloride (also known as ipi-504), a hydroquinone hydrochloride salt derivative of 17-aag, is a novel, potent and selective inhibitor of heat shock protein 90(hsp90) that binds to the amino-terminal atp/adp-binding site of hsp90. as a highly water-soluble version of 17-aag, ipi-504 (solubility > 200 mg/ml) does not need prior dissolution in organic solvents and hence can be delivered in high concentrations. once in the systemic circulation, ipi-504 is deprotonated and converted into the free base ipi-504 which is subsequently oxidized to 17-aag. ipi-504 potently inhibits proliferation in several tumor cell lines with 50% inhibition concentration ic50 values ranging from 10-40 nmol/l and has been used for the treatment of gastrointestinal stromal tumors, soft-tissue sarcomas and non-small cell lung cancer.britt erika hanson and david h vesole. retaspimycin hydrochloride (ipi-504): a novel heat shock protein inhibitor as an anticancer agent. expert opin. investi. drugs (2009) 18(9): 1375-1383david siegel, sundar jagannath, david h. vesole, ivan borello, amitabha mazumder, constantine mitsiades, jill goddard, joi dunbar, emmanuel normant, julian adams, david grayzel, kenneth c. anderson and paul richardson. a phase 1 study of ipi-504 (retaspimycin hydrochloride) in patients with relapsed or relapsed and refractory multiple myeloma. leukemia & lymphoma, 2011; 52(12): 2308-2315ching ching leow, jon chesebrough, karen t. coffman, christine a. fazenbaker, john gooya, david weng, steve coats, dowdy jackson, bahija jallal and yong chang. antitumor efficacy of ipi-504, a selective heat shock protein 90 inhibitor against human epidermal growth factor receptor 2-positive human xenograft models as a single agent and in combination with trastuzumab or lapatinib. mol cancer ther 2009; 8: 2131-2141 | | target | HSP90 |
| | Retaspimycin Hydrochloride Preparation Products And Raw materials |
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