Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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Tel: |
821-50328103-801 18930552037 |
Email: |
3bsc@sina.com |
Products Intro: |
Product Name:JNJ 5207787;(2E)-N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyanophenyl)-N-[1-(2-cyclopentylethyl)-4-piperidinyl]-2-propenaMide CAS:683746-68-1 Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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Company Name: |
Amatek Scientific Co. Ltd.
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Tel: |
0512-56316828 |
Email: |
info@amateksci.com |
Products Intro: |
Product Name:JNJ 5207787 CAS:683746-68-1 Purity:97% HPLC Package:5g;25g;100g;1kg
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Company Name: |
BOC Sciences
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Tel: |
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Email: |
info@bocsci.com |
Products Intro: |
Product Name:JNJ 5207787 CAS:683746-68-1 Purity:≥98% by HPLC Remarks:JNJ 5207787 has been found to be a selective NPY Y2 antagonist (IC50 = 0.1 μM).
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| (2E)-N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyanophenyl)-N-[1-(2-cyclopentylethyl)-4-piperidinyl]-2-propenamide Basic information |
| (2E)-N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyanophenyl)-N-[1-(2-cyclopentylethyl)-4-piperidinyl]-2-propenamide Chemical Properties |
density | 1.22 | storage temp. | Store at RT | solubility | Soluble to 10 mM in DMSO with gentle warming and to 10 mM in ethanol with gentle warming | form | Powder |
| (2E)-N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyanophenyl)-N-[1-(2-cyclopentylethyl)-4-piperidinyl]-2-propenamide Usage And Synthesis |
Description | JNJ-5207787 is an antagonist of the neuropeptide Y (NPY) receptor Y2 that blocks peptide YY binding (IC50 = 100 nM). It displays 100-fold selectivity for Y2 over other NPY receptors and has minimal effect on a panel of 50 receptors, ion channels, and transporters, except for sodium channel 2. JNJ-5207787 is intraperitoneally bioavailable and brain penetrant in rats, occupying maximally 50% of Y2 receptor binding sites in the hypothalamic area. | Uses | JNJ 5207787 is a small molecule antagonist of the neuropeptide Y Y2 receptor. |
| (2E)-N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyanophenyl)-N-[1-(2-cyclopentylethyl)-4-piperidinyl]-2-propenamide Preparation Products And Raw materials |
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