CP 465022 HYDROCHLORIDE
中文名称 | CP 465022 HYDROCHLORIDE |
---|---|
中文同义词 | 3-(2-氯苯基)-2-[2-[6-[(二乙基氨基)甲基]-2-吡啶基]乙烯基]-6-氟-4(3H)喹唑啉酮;CP 465022游离的;CP 465022盐酸盐 |
英文名称 | 3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride |
英文同义词 | 3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride;CP 465022 hydrochloride;CP465022HCl;CP465022; CP-465022;3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinone;CP 465022 hydrochloride,3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride;4(3H)-Quinazolinone, 3-(2-chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-;CP 465022 hydrochlor |
CAS号 | 199655-36-2 |
分子式 | C26H24ClFN4O |
分子量 | 462.95 |
EINECS号 | 200-158-5 |
相关类别 | 对照品 |
Mol文件 | 199655-36-2.mol |
结构式 |
CP 465022 HYDROCHLORIDE 性质
沸点 | 585.0±60.0 °C(Predicted) |
---|---|
密度 | 1.23±0.1 g/cm3(Predicted) |
储存条件 | Desiccate at RT |
溶解度 | 不溶于水; <49.94mg/ml,溶于 DMSO |
形态 | 固体 |
酸度系数(pKa) | 8.51±0.25(Predicted) |
颜色 | 粘黄色 |
IC50: 25 nM (rat cortical neurons)
CP-465022 (0.0001 μM-10 μM) inhibits kainate-induced response in relatively slow manner and dependents on compound concentration, exhibiting a calculated IC 50 of 25 nM and essentially complete inhibition at 3.2 µM. CP-465022 1 µM for 10 min has little effect on peak NMDA-induced currents but reduces current measured at 8 s during NMDA application by 26%.CP-465,022 at 10 µM inhibits peak NMDA-induced currents in cortical neurons by 36% and currents measured at 8 s by 70% d in primary cultures of cortical and cerebellar granule neurons. CP-465022 1 µM for 10 min inhibits peak NMDA currents in cultured rat cerebellar granule neurons with mean inhibition of 19% and NMDA currents measured at 8 s by 45%, similar to what is observed in the cortical neurons.CP-465022 (100 nM -10 µM) has inhibitory effects on Kainate-induced whole-cell currents in voltage-clamped rat hippocampal, 100 nM CP465,022 inhibits kainate currents developed over the course of 200s, 500 nM and 1 µM CP-465,022 nearly complete inhibits this time frame (99.3%).
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2023/03/20 | HY-18663B | CP 465022 HYDROCHLORIDE CP-465022 hydrochloride | 199655-36-2 | 5 mg | 6900元 |
2023/03/20 | HY-18663B | CP 465022 HYDROCHLORIDE CP-465022 hydrochloride | 199655-36-2 | 10 mg | 11000元 |