ProTx II manufacturers
- ProTx II USP/EP/BP
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- $1.10 / 1g
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2021-08-07
- CAS:484598-36-9
- Min. Order: 1g
- Purity: 99.9%
- Supply Ability: 100 Tons min
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| | ProTx II Basic information | | Uses |
| Product Name: | ProTx II | | Synonyms: | ProTx II;ProToxin-II;PT-II;ProTx II USP/EP/BP;Cys15-Cys25);H-Tyr-Cys-Gln-Lys-Trp-Met-Trp-Thr-Cys-Asp-Ser-Glu-Arg-Lys-Cys-Cys-Glu-Gly-Met-Val-Cys-Arg-Leu-Trp-Cys-Lys-Lys-Lys-Leu-Trp-OH(Disulfide bridge：Cys2-Cys16;Met6-Cys21;ProTx II，TFA | | CAS: | 484598-36-9 | | MF: | C168H250N46O41S8 | | MW: | 3826.5862 | | EINECS: | | | Product Categories: | | | Mol File: | 484598-36-9.mol |  |
| | ProTx II Chemical Properties |
| storage temp. | -20°C | | solubility | Soluble to 0.10 mg/ml in 4:1 Acetonitrile : water | | form | Powder | | Water Solubility | Soluble to 1 mg/ml in water |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 45 |
| | ProTx II Usage And Synthesis |
| Uses | ProTx-II is a potent, selective Nav1.7 blocker. Voltage-gated sodium channels (Nav) are responsible for transducing extracellular signals into action potentials in excitable cells. The Nav1 family consists of nine sub-types for which selective tools are highly valued. Discovery of subtype-selective tools has been challenging due to conservation of putative binding sites. Nav1.7 is expressed in sensory neurons and is critical for pain processing. ProTx-II, isolated from the tarantula Thrixopelma pruriens, is a potent blocker of Nav1 channels. Although ProTx-II blocks several members of this channel family, it has >100-fold selectivity for Nav1.7. ProTx-II is active in an in vitro model of pain processing. ProTx-II binds to a previously unknown site on the channel, conferring selectivity and increasing its value as a research tool. It blocks Nav1.7 by decreasing conductance and shifting the activation potential in the positive direction, resulting in an overall decrease in excitability. | | storage | Store at -20°C |
| | ProTx II Preparation Products And Raw materials |
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