|
|
| | BAY-41-8543 Basic information |
| Product Name: | BAY-41-8543 | | Synonyms: | BAY-41-8543;BAY-41-8543 Exclusive;BAY 41-8543
(BAY 418543);2-[1-[(2-Fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(4-morpholinyl)-4,6-pyrimidinediamine;4,6-Pyrimidinediamine, 2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(4-morpholinyl)-;BAY 418543,vascular,systemic,antiplatelet,vasodilator,soluble,pulmonary,orally,nitric,beds,cardiovascular,BAY 41 8543,Guanylate Cyclase,Inhibitor,sGC,BAY 41-8543,oxide,inhibit;2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]-5-morpholin-4-ylpyrimidine-4,6-diamine | | CAS: | 256498-66-5 | | MF: | C21H21FN8O | | MW: | 420.44 | | EINECS: | | | Product Categories: | | | Mol File: | 256498-66-5.mol |  |
| | BAY-41-8543 Chemical Properties |
| Boiling point | 599.7±50.0 °C(Predicted) | | density | 1.55±0.1 g/cm3(Predicted) | | solubility | DMF: 3 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml | | form | A crystalline solid | | pka | 5.18±0.10(Predicted) |
| | BAY-41-8543 Usage And Synthesis |
| Uses | BAY 41-8543, is a Guanylyl cyclase (sGC) stimulator, increasing the activity of recombinant sGC dose-dependently, from 0.1 nM to 100 μM, up to 92-fold. BAY 41-8543 reduces pulmonary vascular resistance and protects right ventricular (RV)function. It also inhibits collagen-induced platelet aggregation, and promotes lipid uptake into brown adipose tissue and increases energy expenditure in mice. It has also shown Antihypertensive activity. | | Definition | ChEBI: BAY-41-8543 is a pyrazolopyridine. | | storage | Store at -20°C |
| | BAY-41-8543 Preparation Products And Raw materials |
|