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Amantadine

Amantadine Suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:Amantadine
CAS:768-94-5
Purity:99.00% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:768-94-5
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Shanghai Time Chemicals CO., Ltd.
Tel: +86-021-57951555
Email: jack.li@time-chemicals.com
Products Intro: Product Name:1-Adamantanamine
CAS:768-94-5
Company Name: Mainchem Co., Ltd.
Tel: +86-0592-6210733
Email: sales@mainchem.com
Products Intro: Product Name:Amantadine
CAS:768-94-5
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 86-155-27864001
Email: peter@hubeijusheng.com
Products Intro: Product Name:amantadine
CAS:768-94-5
Purity:99% Package:5KG;1KG Remarks:C10H17N

Lastest Price from Amantadine manufacturers

  • Amantadine
  • US $1.00 / KG
  • 2018-08-14
  • CAS:768-94-5
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 1ton
Amantadine Basic information
Inhibitor
Product Name:Amantadine
Synonyms:Tricyclo[3.3.1.1(3,7)]decan-1-amine;tricyclo[3.3.1.13,7]decan-1-amine;Symadine;adamantan-1-amine;AMANTADINE HCL USP(CRM STANDARD);AmantadineHclUsp27;1-Adamantylamine (base and/or unspecified salts);AMANTADINEBASE
CAS:768-94-5
MF:C10H17N
MW:151.25
EINECS:212-201-2
Product Categories:Adamantane derivatives;A-AM;Amines;Bioactive Small Molecules;Building Blocks;C10;neurochemistry;Cell Biology;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks
Mol File:768-94-5.mol
Amantadine Structure
Amantadine Chemical Properties
Melting point 206-208 °C(lit.)
Boiling point 263.29°C (rough estimate)
density 0.9510 (rough estimate)
refractive index 1.5220 (estimate)
solubility 1 M HCl: soluble5%, clear to hazy, colorless to faint yellow or tan
form Powder
pka10.1(at 25℃)
color White to cream
Water Solubility Soluble in organic solvents. Insoluble in water.
Merck 14,374
BRN 2204333
InChIKeyDKNWSYNQZKUICI-UHFFFAOYSA-N
CAS DataBase Reference768-94-5(CAS DataBase Reference)
NIST Chemistry ReferenceTricyclo[3.3.1.13,7]decane-1-amine(768-94-5)
EPA Substance Registry SystemTricyclo[3.3.1.13, 7]decan-1-amine(768-94-5)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-36/37/38
Safety Statements 26-36
WGK Germany 3
RTECS YD1925000
10-34
HS Code 29213000
Hazardous Substances Data768-94-5(Hazardous Substances Data)
MSDS Information
ProviderLanguage
Amantadine English
SigmaAldrich English
Amantadine Usage And Synthesis
InhibitorThe anti-influenza A compound amantadine acts by blocking the M2 ion channel which is required for uptake of protons into the interior of the virus to permit acid-promoted viral uncoating (decapsidation).
Chemical PropertiesWhite to cream powder
UsesBuilding block for an L-piperidinamide catalyst used in an enantioselective Strecker reaction of phosphinoyl imines.1
DefinitionChEBI: A member of the class of adamantanes that is used as an antiviral and antiparkinson drug.
Brand nameSymadine (Solvay Pharmaceuticals); Symmetrel (Endo).
Antimicrobial activityIt inhibits influenza A virus replication at concentrations of 0.2– 0.6 mg/L, but has little or no activity against influenza B or C.
Acquired resistanceResistance is the consequence of mutations in amino acid positions 27, 30 and 31 in the M2 transmembrane sequence. Cross-resistance between amantadine and rimantadine is universal. Influenza H3N2 strains worldwide are now resistant, but seasonal H1N1 strains remain susceptible. Postexposure family prophylaxis results in the prompt emergence of drug resistance after onset of treatment.
Pharmaceutical ApplicationsA symmetrical synthetic C-10 tricyclic amine with an unusual cage-like structure, supplied as the hydrochloride for oral administration.
PharmacokineticsOral absorption: >90%
Cmax 200 mg oral per day: 0.4–0.9 mg/L after c. 4–6 h
Plasma half-life: 9.7–14.5 h
Volume of distribution: 10.4 L/kg
Plasma protein binding: 65%
Absorption and distribution
Absorption after oral administration is almost complete. Levels in secretions approach plasma concentrations.
Metabolism and excretion
About 56% of a single oral dose is excreted unchanged within 24 h by the kidney. Altogether 90% of an oral dose is excreted in the urine with a mean elimination half-life of 11.8 h in subjects with normal renal function. In elderly men, the half-life is 28.9 h and in patients with renal insufficiency half-lives of 18.5 h to 33.8 days have been observed. The renal clearance is around 398 mL/min (range 112–772 mL/min), indicating active secretion as well as glomerular filtration. Less than 5% of a dose is removed during hemodialysis and average half-lives of 8.3 and 13 days have been reported in patients on chronic hemodialysis. Extreme care must be taken to ensure that drug does not accumulate to toxic levels.
Clinical UsePrevention and treatment of influenza A H1N1 infections
Side effectsEmbryotoxicity and teratogenicity have been observed in rats receiving 50 mg/kg per day, about 15 times the usual human dose. Neurological side effects include drowsiness, insomnia, light-headedness, difficulty in concentration, nervousness, dizziness and headache in up to 20% of individuals. Other side effects include anorexia, nausea, vomiting, dry mouth, constipation and urinary retention. All develop during the first 3–4 days of therapy and are reversible by discontinuing the drug. An exception to rapid onset of adverse reactions is livedo reticularis. Convulsions, hallucinations and confusion are dose related, usually occurring at levels in excess of 1.5 mg/L; convulsions may occur at a lower threshold in patients with a history of epilepsy and the drug is best avoided in such patients.
Purification MethodsDissolve the amine in Et2O, dry it over KOH, evaporate and sublime it in vacuo. [Stetter et al. Chem Ber 93 226 1960.]
Amantadine Preparation Products And Raw materials
Preparation Products1-Adamantanamine hydrochloride
Raw materialsBromine-->Adamantane-->Distillator-->Industrial glass lining reaction vessel
Tag:Amantadine(768-94-5) Related Product Information
AMANTADINE SULFATE 99+%,TRICYCLO[3.3.1.13.7]DECAN-1-AMINE SULFATE (AMANTADINE SULFATE),amantadine sulphate (INNM) ,AMANTADINE SULFATE,AMANTADINE SULPHATE 1-(1-ADAMANTYL)-4-METHYLPYRIDINIUM BROMIDE 1-ADAMANTYL ISOCYANATE N-(1-Adamantyl)acetamide N-(1-ADAMANTYL)ACRYLAMIDE N-(1-ADAMANTYL)UREA SALOR-INT L130907-1EA 4-[(1-ADAMANTYLAMINO)METHYL]-1(2H)-PHTHALAZINONE 1-(1-ADAMANTYL)PYRIDINIUM BROMIDE 1-ADAMANTYL ISOTHIOCYANATE AKOS BBS-00002356 Altrenogest diethanolamine AMANTADINE HYDROCHLORIDE,AMANTADINE HCL,AMANTADINE HYDROCHLORIDE, PHARMA,1-Adamantanamine hydrochloride, 1-Adamantylamine hydrochloride, Amantadine hydrochloride Amantadine Decane COCO AMINE Bis(2-ethylhexyl)amine