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Belinostat (PXD101)

Belinostat (PXD101) Suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: 571-85586718 +8613336195806
Email: sales@capotchem.com
Products Intro: Product Name:Belinostat
CAS:414864-00-9
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:belinostat
CAS:414864-00-9
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: career henan chemical co
Tel: +86-0371-86658258
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Products Intro: Product Name:Belinostat (PXD101)
CAS:414864-00-9
Purity:98% Package:1KG;1USD
Company Name: Hubei xin bonus chemical co. LTD
Tel: 86-13657291602
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Products Intro: Product Name:Belinostat (PXD101)
CAS:414864-00-9
Purity:0.99 Package:5KG;1KG
Company Name: BOC Sciences
Tel: +1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:Belinostat
CAS:414864-00-9
Package:100mg Remarks:BOC Sciences also provides custom synthesis services for Belinostat.

Belinostat (PXD101) manufacturers

  • Belinostat (PXD101)
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  • $1.00 / 1KG
  • 2019-07-06
  • CAS:414864-00-9
  • Min. Order: 1G
  • Purity: 98%
  • Supply Ability: 100KG

Related articles

  • Uses of Belinostat
  • Belinostat is a novel agent that inhibits the enzyme histone deacetylase (HDAC) with a sulfonamide-hydroxamide structure. It w....
  • Oct 21,2019
Belinostat (PXD101) Basic information
Product Name:Belinostat (PXD101)
Synonyms:PXD101, Beliomsta;BELINOSTAT (PXD101);PXD101;N-HYDROXY-3-[3-[(PHENYLAMINO)SULFONYL]PHENYL]-2-PROPENAMIDE;N-HYDROXY-3-(3-PHENYLSULFAMOYLPHENYL)ACRYLAMIDE;Belinostat(PXD101);2-PropenaMide, N-hydroxy-3-[3-[(phenylaMino)sulfonyl]phenyl]-;PX105684;Belinostat-13C6
CAS:414864-00-9
MF:C15H14N2O4S
MW:318.35
EINECS:
Product Categories:Inhibitors;API;Inhibitor
Mol File:414864-00-9.mol
Belinostat (PXD101) Structure
Belinostat (PXD101) Chemical Properties
Melting point 142 - 145°C
density 1.427±0.06 g/cm3(Predicted)
storage temp. Amber Vial, Refrigerator, Under inert atmosphere
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka8.31±0.10(Predicted)
color Off-White to Pale Orange
Stability:Light Sensitive
Safety Information
HS Code 29350090
MSDS Information
Belinostat (PXD101) Usage And Synthesis
DescriptionBelinostat is a drug which was developed by Spectrum Pharmaceuticals and is currently marketed by Onxeo as Beleodaq®. The drug, which received fast track designation by the United States Food and Drug Administration (US FDA) and was approved for the treatment of hematological malignancies and solid tumors associated with peripheral T-cell lymphoma (PTCL) in 2014, is a histone deacetylase (HDAC) inhibitor and is the third such treatment to receive accelerated approval for PTCL, the others being vorinostat (Zolinza®) and pralatrexate (Folotyn®). Although belinostat was not yet approved in Europe as of August 2014, the compound exhibits a safety profile considered to be acceptable for HDAC inhibitors–less than 25% of patients reported adverse effects and these most frequently were nausea, fatigue, pyrexia, anemia, and emesis.
UsesBelinostat is a novel histone deacetylase 3 selective inhibitor, which protects the β cells from cytokine-induced apoptosis.
DefinitionChEBI: A hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity.
SynthesisCommercially available 3-bromobenzenesulfonyl chloride (41) was reacted with aniline in the presence of aqueous sodium carbonate to deliver sulfonamide 42 in 94% yield. Next, this aryl bromide was subjected to a Heck reaction involving ethyl acrylate to give rise to cinnamate ester 43, which was immediately saponified under basic conditions and acidic workup to furnish the corresponding acid 44. This acid was activated as the corresponding acid chloride prior to subjection to hydroxylamine under basic conditions to form the hydroxamic acid, which was then recrystallized from an 8:1 ethanol/water mixture in the presence of a catalytic amount of sodium bicarbonate to furnish crystalline belinostat (VI) in 87% overall yield from acid 44.

Synthesis_414864-00-9

targetpan-HDAC
Belinostat (PXD101) Preparation Products And Raw materials
Tag:Belinostat (PXD101)(414864-00-9) Related Product Information
PXD-101 N-[(2,3-dimethoxyphenyl)methyl]-3,4-dimethoxy-benzeneethanamine hydrochloride 2-Propenoic acid, 3-[3-[(phenylaMino)sulfonyl]phenyl]-, ethyl ester, (2E)- 1,4-Bis[(4-chlorophenyl)-phenylMethyl]piperazine Panobinostat JNJ-26481585 Mocetinostat (MGCD0103) Vorinostat Entinostat CRA-02478 cinnamoylhydroxamic acid Belinostat (PXD101)