|
|
| | AMG 487 Basic information |
| Product Name: | AMG 487 | | Synonyms: | AMG 487;N-[(1R)-1-[3-(4-Ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(3-pyridinylmethyl)-4-(trifluoromethoxy)benzeneacetamide;Benzeneacetamide, N-[(1R)-1-[3-(4-ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(3-pyridinylmethyl)-4-(trifluoromethoxy)-;(R)-N-(1-(3-(4-Ethoxyphenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)ethyl)-N-(pyridin-3-ylmethyl)-2-(4-(trifluoromethoxy)phenyl)acetamide;Metastatic,metastasis,inhibit,cancer,CXCL11,CXC chemokine receptors,AMG-487,AMG487,CXCL10,chemokine,receptor,CXCR3,AMG 487,CXCR,Inhibitor,Breast,colon | | CAS: | 473719-41-4 | | MF: | C32H28F3N5O4 | | MW: | 603.59 | | EINECS: | | | Product Categories: | | | Mol File: | 473719-41-4.mol |  |
| | AMG 487 Chemical Properties |
| Melting point | 161.2℃ (ethyl acetate heptane ) | | storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C | | solubility | DMSO:41.0(Max Conc. mg/mL);67.93(Max Conc. mM) | | form | A crystalline solid |
| | AMG 487 Usage And Synthesis |
| Uses | N-[(1R)-1-[3-(4-Ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(3-pyridinylmethyl)-4-(trifluoromethoxy)benzeneacetamide is a selective and potent antagonist of the chemokine receptor CXCR3. |
| | AMG 487 Preparation Products And Raw materials |
|