ChemicalBook > Product Catalog >Pharmaceutical intermediates >Bulk Drug Intermediates >TAK-438


TAK-438 Suppliers list
Company Name: CE Pharm Co.,Ltd
Tel: +86 13816833708
Products Intro: Product Name:TAK 438,Vonoprazan
Purity:0.99 Package:1KG;25KG
Company Name: Jinan Ande Pharmaceutical Co.,Ltd.
Products Intro: Product Name:Vonoprazan fumarate
Purity:99% Package:1KG;5KG;10KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Products Intro: Product Name:AK-438
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: 008615858145714
Products Intro: Product Name:Vonoprazan fumarate
Purity:As coa Package:As request Remarks:1260141-27-2
Tel: +86 21 5161 9050/ 5187 7795
Products Intro: Product Name:Vonoprazan
Purity:0.99 Package:5G,10G,25G,50G,100G,250G,1KG

Lastest Price from TAK-438 manufacturers

  • Vonoprazan Fumarate
  • US $0.00-0.00 / KG
  • 2021-09-17
  • CAS:1260141-27-2
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 1000KG
  • Vonoprazan fumarate
  • US $29.99 / KG
  • 2021-09-02
  • CAS:1260141-27-2
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 50ton
  • TAK-438
  • US $20.00 / KG
  • 2021-08-18
  • CAS:1260141-27-2
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 9000kg/per week
TAK-438 Basic information
Product Name:TAK-438
Synonyms:Vonaprazan;5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine 2-butenedioate (Vonoprazan);1-[5-(2-fluorophenyl)-1-pyridin-3-ylsulfonylpyrrol-3-yl]-N-methylmethanamine;AK-438;Vonaprazan(TAK-438);vonoprazan(tak-438);Vonoprazan fumarate(TAK-438);vonoprazan(tak-438)1260141-27-2
Product Categories:Vonoprazan;Inhibitors;API
Mol File:1260141-27-2.mol
TAK-438 Structure
TAK-438 Chemical Properties
Safety Information
MSDS Information
TAK-438 Usage And Synthesis
DescriptionVonoprazan fumarate (Takecab®), discovered and developed by Takeda and Otsuka, was approved by the PMDA of Japan in December 2014, and is indicated for the treatment of gastric ulcer, duodenal ulcer and reflux esophagitis. Vonoprazan fumarate has a novel mechanism of action called potassium-competitive acid blockers, which competitively inhibit the binding of potassium ions to H+, K+-ATPase (also known as the proton pump) in the final step of gastric acid secretion in gastric parietal cells. Vonoprazan does not inhibit Na+, K+-ATPase activity even at concentrations 500 times higher than that of their IC50 values against gastric H+, K+-ATPase activity. Furthermore, the drug is unaffected by the gastric secretory state, unlike PPIs.
Chemical SynthesisCommercially available 2-fluoroacetophenone (283) was brominated to yield a-bromo-acetophenone derivative 284. This compound was treated with ethyl 2-cyanoacetate (285) under basic conditions to provide ketoester 286 in essentially quantitative yield. Next, intramolecular condensation of 286 upon treatment of 4 M HCl furnished the tri-substituted pyrrole 287 in 53% yield. Reduction of the chloride under hydrogenolytic conditions facilitated arrival at pyrrole 288, albeit in just 18% yield. Subsequent diisobutylaluminium hydride (DIBAL) reduction, followed by the oxidation with tetrapropylammonium perruthenate (TPAP) and 4-methylmorpholine N-oxide (NMMO) afforded the corresponding aldehyde 290 in 60% yield across the 2 steps. Next, N-pyrrole substitution with pyridine- 3-sulfonyl chloride 291 gave rise to N-sulfonylpyrrole 292 in 82% yield. Reductive amination of 292 afforded amine 293, which was treated with fumaric acid (294) via co-crystallization to provide vonoprazan fumarate (XXXVI) in 74% for the two steps.

TAK-438 Preparation Products And Raw materials
Tag:TAK-438(1260141-27-2) Related Product Information
1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)- 1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)- ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) Fosaprepitant dimeglumine ETOFIBRATE Donepezil Hydrochloride AGOMELATINE Linagliptin Alogliptin benzoate Trelagliptin Trelagliptin succinate Teneligliptin Esomeprazole R-(+)-Lansoprazole 2-PYRIMIDINAMINE, 4-(3,4-DIHYDRO-1-METHYL-2(1H)-ISOQUINOLINYL)-N-(4-FLUOROPHENYL)-5,6-DIMETHYL-, MONOHYDROCHLORIDE Pantoprazole Lansoprazole Vonoprazan