MI 63 manufacturers
- MI-63
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- $2500.00
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2026-04-20
- CAS:908027-21-4
- Purity:
- Supply Ability: 10g
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| Product Name: | MI 63 | | Synonyms: | MI 63;(2'R,3S,3'S,5'R)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide;Spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide, 6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-N-[2-(4-morpholinyl)ethyl]-2-oxo-, (2'R,3S,4'S,5'R)- | | CAS: | 908027-21-4 | | MF: | C29H35Cl2FN4O3 | | MW: | 577.52 | | EINECS: | | | Product Categories: | | | Mol File: | 908027-21-4.mol |  |
| | MI 63 Chemical Properties |
| Boiling point | 732.3±60.0 °C(Predicted) | | density | 1.35±0.1 g/cm3(Predicted) | | pka | 12.04±0.70(Predicted) |
| | MI 63 Usage And Synthesis |
| Description | MI-63 is a potent, specific, non-peptide inhibitor of the MDM2-p53 interaction. | | Uses | MI 63 is an activator for p53, by targeting the MDM2 (Ki is 3 nM). MI 63 inhibits the proliferation of embryonic and alveolar rhabdomyosarcoma (ERMS and ARMS) cells (IC50 is 0.58 μM in RH36 cells), and induces apoptosis in ERMS and ARMS[1]. | | Definition | ChEBI: MI-63 is an azaspiro compound resulting from the formal fusion of position 3 of 6-chloro-oxindole with position 3 of (2R,3SS5S)-3-(3-chloro-2-fluorophenyl)-5-(2,2-dimethylpropyl)-N-[2-(morpholin-4-yl)ethyl]pyrrolidine-2-carboxamide. It is a potent inhibitor of the MDM2-p53 interaction. It has a role as an apoptosis inducer. It is an azaspiro compound, a member of morpholines, a member of oxindoles, a member of pyrrolidines, a member of monochlorobenzenes, a member of monofluorobenzenes and a secondary carboxamide. | | References | [1] Canner JA, et al., MI-63: a novel small-molecule inhibitor targets MDM2 and induces apoptosis in embryonal and alveolar rhabdomyosarcoma cells with wild-type p53. Br J Cancer. 2009 Sep 1;101(5):774-81. DOI:10.1038/sj.bjc.6605199 |
| | MI 63 Preparation Products And Raw materials |
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