- Auristatin E
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- $0.00 / 10g
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2021-09-16
- CAS:160800-57-7
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 100KG
- Auristatin E
-
- $15.00 / 1KG
-
2021-07-13
- CAS:160800-57-7
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- Auristatin E
-
- $15.00 / 1KG
-
2021-07-09
- CAS:160800-57-7
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| | Auristatin E Basic information |
| Product Name: | Auristatin E | | Synonyms: | Auristatin E;L-Valinamide, N,N-dimethyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-;Auristatin E,inhibit,ADC Payload,ADC Cytotoxin,Inhibitor,Microtubule/Tubulin;(S)-2-((S)-2-(Dimethylamino)-3-methylbutanamido)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)-N,3-dimethylbutanamide;(2S)-2-[(2S)-2-(dimethylamino)-3-methylbutanamido]-N-[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-2-{[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]carbamoyl}-1-methoxy-2-methylethyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N,3-dimethylbutanamide | | CAS: | 160800-57-7 | | MF: | C40H69N5O7 | | MW: | 732.01 | | EINECS: | | | Product Categories: | | | Mol File: | 160800-57-7.mol |  |
| | Auristatin E Chemical Properties |
| Melting point | 92-94 °C | | Boiling point | 871.0±65.0 °C(Predicted) | | density | 1.085±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C,unstable in solution, ready to use. | | solubility | Soluble in DMSO | | form | Solid | | pka | 13.66±0.20(Predicted) | | color | White to light yellow |
| | Auristatin E Usage And Synthesis |
| Description | Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity; it is a synthetic analog of dolastatin 10. Auristatin E is a highly potent antimitotic agent. Auristatin E inhibits tubulin polymerization(1). Auristatin E-antibody cunjugates have proven to be successful anticancer agents.(2)
Ref. 1. Pettit et al. Anticancer Drug Des. 1995 10:529.
Ref. 2. Doronina et al. Nature Biotechnol. 2003 21:778. |
| | Auristatin E Preparation Products And Raw materials |
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