| Company Name: |
J & K SCIENTIFIC LTD.
|
| Tel: |
18210857532; 18210857532 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]propanenitrile
CAS:1111636-35-1
Package:50Mg,5Mg
|
| Company Name: |
Jinan Trio PharmaTech Co., Ltd.
|
| Tel: |
0531-88811783 |
| Email: |
sales@trio-pharmatech.com |
| Products Intro: |
Product Name:PF-04880594
CAS:1111636-35-1
Purity:99% Package:5Mg, 10Mg, 20Mg, 50Mg
|
| Company Name: |
AdooQ Bioscience CHINA
|
| Tel: |
025-58849295 18951903616; |
| Email: |
info@adooq.cn |
| Products Intro: |
Product Name:PF-04880594
CAS:1111636-35-1
Purity:0.98 Package:1mg;5mg;10mg;25mg;50mg;100mg
|
Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]- manufacturers
- PF-04880594
-
- $2500.00 / 100mg
-
2025-10-27
- CAS:1111636-35-1
- Min. Order:
- Purity:
- Supply Ability: 10g
|
| | Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]- Basic information |
| Product Name: | Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]- | | Synonyms: | Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]-;PF-04880594;3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]propanenitrile;3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyrazol-4-yl]pyrimidin-2-yl]amino]propanenitrile;PF-04880594/PF04880594;CS-727;3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]propanenitrile
DISCONTINUED | | CAS: | 1111636-35-1 | | MF: | C19H16F2N8 | | MW: | 394.38 | | EINECS: | | | Product Categories: | | | Mol File: | 1111636-35-1.mol | ![Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]- Structure](CAS/GIF/1111636-35-1.gif) |
| | Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]- Chemical Properties |
| density | 1.48±0.1 g/cm3(Predicted) | | storage temp. | room temp | | solubility | Soluble in DMSO | | pka | 12.99±0.40(Predicted) | | form | powder | | color | white to beige |
| | Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]- Usage And Synthesis |
| Uses | 3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]propanenitrile is a pyrazole compound and a potential Raf inhibitors. | | Biochem/physiol Actions | PF-04880594 is a potent and selective RAF inhibitor that inhibits both wild-type and mutant BRAF and CRAF. PF-04880594 potently inhibits tumor growth in BRAF-mutant melanoma xenograft models. | | in vivo | PF-04880594 (10 mg/kg) induces ERK phosphorylation and BRAF-CRAF dimerization in multiple epithelial tissues in mice and the induction can be attenuated by PD0325901[1].
PF-04880594 (0-40 mg/kg, twice daily for 3 weeks) induces epithelial hyperplasia in mice and the induction is prevented by PD0325901[1]. | Animal Model: | Nude mice[1] | | Dosage: | 10 mg/kg alone or in combination with 0.5 mg/kg PD-0325901 | | Administration: | An am and pm dose on day 1 and then an am dose on day 2 approximately 2 hours before the animals were necropsied and the tissues harvested | | Result: | Induced ERK phosphorylation in urinary bladder, tongue, skin, and esophagus tissues.
The induction of ERK phosphorylation was attenuated by cotreatment with 0.5 mg/kg PD0325901.
|
| Animal Model: | Nude mice (6–8 weeks old)[1] | | Dosage: | 10, 20 and 40 mg/kg alone or in combination with 0.1, 0.3, 0.5, 1.0, or 2.5 mg/kg PD-0325901 | | Administration: | Twice daily for 3 weeks | | Result: | Tissues treated with the RAF inhibitor alone display the microscopic pathology typical of unopposed BRAF inhibition. Hyperplasia in nonglandular stomach epithelium was blocked by PD-0325901. |
| | target | BRAFV599E | | IC 50 | Braf; CRAF |
| | Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]- Preparation Products And Raw materials |
|