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L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]-

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L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]- Suppliers list
Company Name: Henan Fengda Chemical Co., Ltd
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Products Intro: Product Name:L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]-
CAS:159857-81-5
Purity:99% Package:1KG;50USD|1000KG;1USD
Company Name: Hangzhou FandaChem Co.,Ltd.
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Products Intro: Product Name:Mc-Val-Cit-PABC-PNP
CAS:159857-81-5
Purity:As coa Package:As request Remarks:159857-81-5
Company Name: ATK CHEMICAL COMPANY LIMITED
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Products Intro: Product Name:MC-Val-Cit-PAB-PNP
CAS:159857-81-5
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
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Products Intro: Product Name:L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]-
CAS:159857-81-5
Purity:98% Package:1g,25g,100g
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Products Intro: Product Name:MC-Val-Cit-PABC
CAS:159857-81-5
Purity:98% HPLC LCMS Package:10G;20G

L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]- manufacturers

  • MC-Val-Cit-PAB-PNP
  • MC-Val-Cit-PAB-PNP pictures
  • $0.00 / 5g
  • 2024-03-29
  • CAS:159857-81-5
  • Min. Order: 5g
  • Purity: >97.00%
  • Supply Ability: 5g
  • Mc-Val-Cit-PABC-PNP
  • Mc-Val-Cit-PABC-PNP pictures
  • $0.00 / 1KG
  • 2022-09-29
  • CAS:159857-81-5
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 1ton
L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]- Basic information
Product Name:L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]-
Synonyms:Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate Mc-Val-Cit-PABC-PNP;L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]-;Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate;MC-Val-Cit-PAB-PNP (ADC peptide linker);4-((S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)-5-ureidopentanamido)benzyl 4-nitrophenyl carbonate;MC-VC-PAB-PNP,Mc-Val-Cit-PABC-PNP;MC-VAL-CIT-PABC-PNP;MC-VC-PAB-PNP;MC-VAL-CIT-PAB-PNB;MC-VAL-CIT-PAB-PNP;[4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate
CAS:159857-81-5
MF:C35H43N7O11
MW:737.76
EINECS:
Product Categories:ADCs;ADCs Linkers;ADC-Linker;ADC-Linkers
Mol File:159857-81-5.mol
L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]- Structure
L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]- Chemical Properties
Boiling point 1034.5±65.0 °C(Predicted)
density 1.338±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMF: 25 mg/ml; DMSO: 20 mg/ml; DMSO:PBS(pH 7.2) (1:4): 0.20 mg/ml
form A crystalline solid
pka13.24±0.70(Predicted)
Safety Information
MSDS Information
L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]- Usage And Synthesis
DescriptionMc-Val-Cit-PABC-PNP is a peptide linker molecule used in the synthesis of antibody-drug conjugates (ADCs). It contains a maleimidocaproyl (Mc) group that can be conjugated to an antibody and a p-nitrophenol (PNP) group that allows the peptide to be linked to anticancer compounds, such as doxorubicin or monomethyl auristatin E (MMAE; ). ADCs target specific cell populations to induce a selective response, such as cell death in cancer cells.
UsesMc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker used in the synthesis of antibody-drug conjugates.
L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]- Preparation Products And Raw materials
Raw materialsBIS(4-NITROPHENYL) CARBONATE-->N-Succinimidyl 6-maleimidohexanoate-->4-Aminobenzyl alcohol-->MC-Val-Cit-PAB-->Val-cit-PAB-OH-->H-Cit-PABA-->Fmoc-Cit-PABA-->6-Maleimidocaproic acid-->4-Nitrophenyl chloroformate-->FMOC-L-Valine-->L-Citrulline-->Fmoc-Val-Cit-OH-->FMOC-VAL-OSU-->FMoc-Val-Cit-PAB-->6-Aminocaproic acid
Tag:L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]-(159857-81-5) Related Product Information
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