| Company Name: |
Artis Biotech Co. Ltd.
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| Tel: |
19138486554 18582380095 |
| Email: |
sales@artisbio.com |
| Products Intro: |
Product Name:Cariprazine D6
CAS:1308278-67-2
Purity:98% HPLC Package:5mg 20mg 50mg 100mg 200mg 1g
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| Company Name: |
Chengdu Novel Biomedical Co., Ltd.
|
| Tel: |
028-85255396 18302801538 |
| Email: |
cdnovell@163.com |
| Products Intro: |
Product Name:Cariprazine D6
CAS:1308278-67-2
Purity:98% HPLC Package:100mg；200mg
|
| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
|
| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:Cariprazine-d6
CAS:1308278-67-2
Purity:>98% Package:1mg;10mg;50mg;100mg;
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Cariprazine-d6 manufacturers
- Cariprazine-D6
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- $0.00 / 5mg
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2023-05-27
- CAS:1308278-67-2
- Min. Order: 1mg
- Purity: 96%
- Supply Ability: 50 mg
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| | Cariprazine-d6 Basic information |
| Product Name: | Cariprazine-d6 | | Synonyms: | Cariprazine-d6;N'-[trans-4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-N,N-di(methyl-d3)-urea | | CAS: | 1308278-67-2 | | MF: | C21H32Cl2N4O | | MW: | 427.41 | | EINECS: | | | Product Categories: | | | Mol File: | 1308278-67-2.mol |  |
| | Cariprazine-d6 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO: soluble | | form | A solid |
| | Cariprazine-d6 Usage And Synthesis |
| Description | Cariprazine-d6 is intended for use as an internal standard for the quantification of cariprazine by GC- or LC-MS. Cariprazine is an atypical antipsychotic.1 It binds to dopamine D2L, D2S, and D3 receptors, the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, and 5-HT2B, and histamine H1 and sigma-1 (σ1) receptors (Kis = 0.085-23.44 nM).2 Cariprazine is an antagonist of dopamine D2 and D3 receptors (Kbs = 0.759 and 0.316 nM, respectively, in dopamine-induced [35S]GTPγS binding assays). It is also a partial agonist at these receptors, stimulating inositol phosphate production in murine A9 cells expressing human D2L receptors (EC50 = 3.16 nM) and inhibiting forskolin-induced cAMP accumulation in CHO cells expressing human D3 receptors (EC50 = 2.63 nM). Cariprazine inhibits amphetamine-induced hyperactivity and the conditioned avoidance response in rats (ED50s = 0.12 and 0.84 mg/kg, respectively).3 It also inhibits scopolamine-induced learning deficits in a water labyrinth learning test in rats when administered at doses ranging from 0.02 to 0.08 mg/kg. Formulations containing cariprazine have been used in the treatment of schizophrenia, as well as manic, depressive, or mixed episodes associated with bipolar I disorder. | | References | 1. Mészáros, G.P., Agai-Csongor, E., and Kapás, M. Sensitive LC-MS/MS methods for the quantification of RGH-188 and its active metabolites, desmethyl- and didesmethyl-RGH-188 in human plasma and urine J. Pharm. Biomed. Anal. 48(2),388-397(2008).
2. Kiss, B., Horváth, A., Némethy, Z., et al. Cariprazine (RGH-188), a dopamine D3 receptor-preferring, D3/D2 dopamine receptor antagonist-partial agonist antipsychotic candidate: In vitro and neurochemical profile J. Pharmacol. Exp. Ther. 333(1),328-340(2010).
3. Gyertyán, I., Kiss, B., Sághy, K., et al. Cariprazine (RGH-188), a potent D3/D2 dopamine receptor partial agonist, binds to dopamine D3 receptors in vivo and shows antipsychotic-like and procognitive effects in rodents Neurochem. Int. 59(6),925-935(2011). |
| | Cariprazine-d6 Preparation Products And Raw materials |
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