PF 04418948

PF 04418948 Suppliers list
Tel: +undefined-21-51877795
Products Intro: CAS:1078166-57-0
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G
Company Name: BOC Sciences
Tel: +16314854226
Products Intro: Product Name:PF-04418948
Purity:98% Package:50mg Remarks:BOC Sciences also provides custom synthesis services for PF-04418948.
Company Name: career henan chemical co
Tel: +86-0371-86658258 15093356674;
Products Intro: Product Name:PF 04418948
Purity:97%-99.9% Package:1KG;1USD
Tel: 86-571-88216897,88216896 13588875226
Products Intro: Product Name:PF-04418948
Purity:99% Package:10kg 25kg 200 kilograms per barrel Remarks:good
Company Name: Dideu Industries Group Limited
Tel: +86-29-89586680 +86-15129568250
Products Intro: Product Name:PF 04418948
Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer

PF 04418948 manufacturers

  • PF 04418948
  • PF 04418948 pictures
  • $1.00 / 1KG
  • 2019-12-26
  • CAS:1078166-57-0
  • Min. Order: 1KG
  • Purity: 97%-99.9%
  • Supply Ability: 100kg
PF 04418948 Basic information
Product Name:PF 04418948
Synonyms:1-(4-Fluorobenzoyl)-3-[[(6-methoxy-2-naphthalenyl)oxy]methyl]-3-azetidinecarboxylic acid;PF 04418948;1-(4-FLUOROBENZOYL)-3-[(6-METHOXYNAPHTHALEN-2-YL)OXYMETHYL]AZETIDINE-3-CARBOXYLIC ACID;PF-04418948;PF04418948;PF 04418948;CS-2852;PF-0441848;PF04418948; PF 04418948;3-Azetidinecarboxylic acid, 1-(4-fluorobenzoyl)-3-[[(6-methoxy-2-naphthalenyl)oxy]methyl]-
Product Categories:
Mol File:1078166-57-0.mol
PF 04418948 Structure
PF 04418948 Chemical Properties
Melting point 171-172°C
Boiling point 639.1±55.0 °C(Predicted)
density 1.357±0.06 g/cm3(Predicted)
storage temp. room temp
solubility DMSO: soluble20mg/mL, clear
form powder
color white to beige
Safety Information
WGK Germany 3
MSDS Information
PF 04418948 Usage And Synthesis
Chemical PropertiesWhite Solid
UsesPF-04418948 has been used in TG (trigeminal ganglion) explant culture.
UsesPF 04418948 acts as a novel, potent and selective prostoglandin EP2 receptor antagonist.
Biological Activitypf-04418948 is an orally active, potent and selective prostaglandin ep2 receptor antagonist with an ic50 of 16 nm.prostaglandin e2 (pge2) induces distinct responses through four different ‘e prostanoid’ (ep) receptors. ep2 is a g protein-coupled receptor which signals preferentially through gs proteins. it is far less active at other prostanoid receptors, including other ep receptors. pf-04418948 can be used in both cells and tissues.1: af forselles kj, root j, clarke t, davey d, aughton k, dack k, pullen n. in vitro and in vivo characterization of pf-04418948, a novel, potent and selective prostaglandin ep₂ receptor antagonist. br j pharmacol. 2011 dec;164(7):1847-56. doi: 10.1111/j.1476-5381.2011.01495.x. erratum in: br j pharmacol. 2012 jun;166(3):1192. dosage error in article text. pubmed pmid: 21595651; pubmed central pmcid: pmc3246710.2. birrell ma, maher sa, buckley j, dale n, bonvini s, raemdonck k, pullen n, giembycz ma, belvisi mg. selectivity profiling of the novel ep2 receptor antagonist, pf-04418948, in functional bioassay systems: atypical affinity at the guinea pig ep2 receptor. br j pharmacol. 2013 jan;168(1):129-38. doi: 10.1111/j.1476-5381.2012.02088.x. pubmed pmid: 22747912; pubmed central pmcid: pmc3570009.3. säfholm j, dahlén se, delin i, maxey k, stark k, cardell lo, adner m. pge2 maintains the tone of the guinea pig trachea through a balance between activation of contractile ep1 receptors and relaxant ep2 receptors. br j pharmacol. 2013 feb;168(4):794-806. doi: 10.1111/j.1476-5381.2012.02189.x. pubmed pmid: 22934927; pubmed central pmcid: pmc3631371
Biochem/physiol ActionsPF-04418948 is a PGE2 Receptor (EP2) specific antagonist (IC50 = 16 nM) with greater than 2000-fold selectivity over other EP subtypes. PF-04418948 inhibits EP2 activity in smooth muscle preps from human, dog and mouse.
in vitropf-04418948 inhibited prostaglandin e2 (pge2)-induced growth in camp with a functional kb value of 1.8 nm in cells expressing ep2 receptors.
in vivoin the case of human myometrium, pf-04418948 caused a parallel, rightward shift of the butaprost-induced inhibition of the contractions that was induced by electrical field stimulation with an apparent kb of 5.4 nm. in dog bronchiole and mouse trachea, it produced the same shifts of the pge2-induced relaxation curve with a kb of 2.5 nm and an apparent kb of 1.3 nm respectively. moreover, in the mouse trachea, reversal of the pge2-induced relaxation by pf-04418948 produced an ic50 value of 2.7 rats, pf-04418948 significantly weakens the effects of the ep2-selective agonist butaprost on cutaneous blood flow when given orally. it was selective for ep2 receptors over homologous and unrelated receptors, enzymes and channels.
storageStore at -20°C
PF 04418948 Preparation Products And Raw materials
Tag:PF 04418948(1078166-57-0) Related Product Information
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