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Pranlukast

Pranlukast Suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: +86-571-85586718
Email: sales@capotchem.com
Products Intro: Product Name:Pranlukast
CAS:103177-37-3
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: Product Name:103177-37-3
CAS:103177-37-3
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: 0086 158 5814 5714 (Mobile; WhatsApp; Telegram)
Email: fandachem@gmail.com
Products Intro: Product Name:Pranlukast
CAS:103177-37-3
Purity:as in COA Package:as customers' requirements
Company Name: career henan chemical co
Tel: +86-371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:Pranlukast
CAS:103177-37-3
Purity:98% Package:1KG;1USD
Company Name: Standardpharm Co. Ltd.
Tel: 86-714-3992388
Email: yxzy@std-med.net
Products Intro: Product Name:Pranlukast-d4
CAS:103177-37-3
Purity:0.99 Package:10mg;25mg;50mg;100mg

Lastest Price from Pranlukast manufacturers

  • Pranlukast
  • US $1.00 / KG
  • 2019-07-06
  • CAS:103177-37-3
  • Min. Order: 1G
  • Purity: 98%
  • Supply Ability: 100KG
Pranlukast Basic information
Asthma drugs
Product Name:Pranlukast
Synonyms:N-[4-oxo-2-(2H-tetrazol-5-yl)-1-benzopyran-8-yl]-4-(4-phenylbutoxy)benzamide;PRANLUKAST;4-oxo-8-(4-(4-phenylbutoxy)benzoylamino)-2-(tetrazol-5-yl)-4h-1-benzopyranh;benzamide,n-(4-oxo-2-(1h-tetrazol-5-yl)-4h-1-benzopyran-8-yl)-4-(4-phenylbutox;emihydrate;ONO-RS-411;ONO-RS-411-01;N-[4-keto-2-(2H-tetrazol-5-yl)chromen-7-yl]-4-(4-phenylbutoxy)benzamide
CAS:103177-37-3
MF:C27H23N5O4
MW:481.5
EINECS:808-178-9
Product Categories:Aromatics;Heterocycles;Antiasthmatic;Inhibitors;Intermediates & Fine Chemicals;API;Pharmaceuticals
Mol File:103177-37-3.mol
Pranlukast Structure
Pranlukast Chemical Properties
Melting point 236-238°C
density 1.374±0.06 g/cm3(Predicted)
storage temp. Store at +4°C
pka4.96±0.10(Predicted)
Merck 14,7710
CAS DataBase Reference103177-37-3(CAS DataBase Reference)
Safety Information
Hazard Codes F,C
Risk Statements 11-34
Safety Statements 16-26-36/37/39-45
RTECS CV5647500
ToxicityLD50 in male mice (mg/kg): >1000 i.v. (Toda)
MSDS Information
Pranlukast Usage And Synthesis
Asthma drugsPranlukast is a common respiratory drug, it belongs to asthma drugs , it is the cysteinyl leukotrienes (LTs) receptor antagonist and it can bind to LTC4, LTD4, LTE4 receptors selectively to antagonize their effect . Roles and application are similar to zafirlukast. It is clinically used for the prevention of bronchial asthma. Oral 225mg once, 2 times one day, morning and evening after meal. After taking ,there may be gastrointestinal reactions,or there may be nausea, vomiting, abdominal pain, diarrhea or constipation, sometimes , fever, rash, pruritus and liver function abnormalities such as serum aminotransferase or bilirubin increase are visible . Pregnant women should use with caution , the elderly should take appropriate reductions. This product can not alleviate the onset of asthma.
At present, three leukotriene receptor antagonists are used for the following purposes:
1, zafirlukast :it is effective for mild to moderate asthma ,it can cause improvement in dose-dependent lung function, and reduce the amount of β agonists. Absorption of the product is affected by food, it should not be taken together with food. Oral each 20mg, 2 times/d.
2, montelukast: it is valid for intermittent or persistent asthma in adults and children. This product is approved by the FDA for the treatment of children aged 6 to 12. Absorption of the product is not affected by food, it can be taken with food . Oral each 10mg, once/d.
3, pranlukast :it is used for mild to moderate asthma, pranlukast can increase patients maximum expiratory flow,and improve asthma symptoms, it can be used as a daily treatment of chronic asthma. Each oral 450mg, 2 times/d.
The above information is edited by the chemicalbook of Tian Ye.
DescriptionPranlukast, a novel chromone derivative, was introduced in Japan for the treatment of bronchial asthma and allergic diseases. Pranlukast is a highly potent, selective and competitive antagonist of peptidoleukotrienes with high affinity for the LTD4 receptor. In patients with bronchial asthma, pranlukast was reported to induce significant improvement in both immediate and late asthmatic response induced by antigen. Pranlukast is also being evaluated clinically for the treatment of perennial allergic rhinitis, pediatric asthma, and cutaneous pruritus in dialysis patients. The therapeutic potential of pranlukast in managing irritable bowel syndrome has been suggested.
Chemical PropertiesOff-white solid
OriginatorOno (Japan)
UsesA potent, selective and orally active CysLT receptor antagonist. Leukotriene antagonist. Used as an antiasthmatic
Usesantiasthmatic;leukotriene receptor-1 antagonist
UsesLabeled Pranlukast, intended for use as an internal standard for the quantification of Pranlukast by GC- or LC-mass spectrometry.
Brand nameOnon
Biological ActivitySelective cysteinyl leukotriene receptor 1 (CysLT 1 ) antagonist (IC 50 values are ~ 4-7 and 3620 nM for CysLT 1 and CysLT 2 respectively). Inhibits contraction of airway smooth muscle, microvascular leakage into airways and eosinophil infiltration. Can decrease symptoms of bronchial asthma.
Pranlukast Preparation Products And Raw materials
Tag:Pranlukast(103177-37-3) Related Product Information
Flurbiprofen Zafirlukast Montelukast sodium Butoxybenzene Pranlukast 8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran 4-ETHOXY-N-PHENYLBENZAMIDE 3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE 3-Amino-2-hydroxyacetophenone 4-ethoxy-N-(2-methoxyphenyl)benzamide 4-METHOXY-N-(2-METHOXYPHENYL)BENZAMIDE