11H-茚并[1,2-b]喹喔啉-11-酮肟
中文名称 | 11H-茚并[1,2-b]喹喔啉-11-酮肟 |
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中文同义词 | 11H-茚并[1,2-B]喹喔啉-11-酮肟;化合物IQ-1S;IQ-1S,JNK3抑制剂 |
英文名称 | IQ-1 sodium |
英文同义词 | 11H-Indeno[1,2-b]quinoxalin-11-one oxime Sodium;IQ-1 sodium;IQ-1S;IQ-1S (free acid);IQ-1S ;IQ 1S ;IQ1S;CS-2230;inhibit,Inhibitor,JNK,IQ1S free acid,IQ 1S free acid |
CAS号 | 23146-22-7 |
分子式 | C15H9N3O |
分子量 | 247.25 |
EINECS号 | |
相关类别 | |
Mol文件 | 23146-22-7.mol |
结构式 |
11H-茚并[1,2-b]喹喔啉-11-酮肟 性质
储存条件 | Sealed in dry,2-8°C |
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溶解度 | DMSO:可溶,2mg/mL,澄清(加热) |
形态 | 粉末 |
颜色 | 白色至米色 |
Target | Value |
JNK3
(Cell-free assay) | 87 nM |
JNK2
(Cell-free assay) | 360 nM |
JNK1
(Cell-free assay) | 390 nM |
Compound IQ-1S is a potent, noncytotoxic inhibitor of pro-inflammatory cytokine [interleukin (IL)-1α, IL-1β, IL-6, IL-10, tumor necrosis factor (TNF)-α, interferon-γ, and granulocyte-macrophage colony-stimulating factor] and nitric oxide production by human and murine monocyte/macrophages. The effect of IQ-1S is evaluated on LPS-induced cytokine production in human PBMCs. Among the 12 cytokines analyzed, LPS (200 ng/mL) consistently induces five (IL-1α, IL-1β, IL-6, IL-10, and TNF-α) in PBMCs compared with DMSO-treated control cells. Production of all of these cytokines is significantly inhibited by 20 μM IQ-1S. Among them, TNF-α production is inhibited completely by IQ-1 (>99%), the levels of IL-1α, IL-1β, and IL-10 are decreased by 85%, and IL-6 production is decreased by 33%.
When mice are dosed with 12.5 and 30 mg/kg IQ-1S (The sodium salt of IQ-1S) i.p., the serum exposure of the compound is also good, with AUC 0-12h values of 2.9 and 7.4 μM/h, respectively.
安全信息
WGK Germany | 3 |
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海关编码 | 2933998090 |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-100233 | 11H-茚并[1,2-b]喹喔啉-11-酮肟 IQ-1S free acid | 23146-22-7 | 5mg | 500元 |
2024/08/19 | HY-100233 | IQ-1S free acid | 10 mM * 1 mLin DMSO | 550元 |