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ChemicalBook > Product Catalog >Organic Chemistry >Amides >Amino compound >N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine

N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine

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N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine Suppliers list
Company Name: Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
Tel: +86-18341751992 +86-15382112998
Email: 757984502@qq.com
Products Intro: Product Name:BC-1215
CAS:1507370-20-8
Purity:0.98 Package:100mg;500mg;1g;5g Remarks:existing product
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:BC-1215
CAS:1507370-20-8
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226
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Products Intro: Product Name:BC-1215
CAS:1507370-20-8
Purity:99% Package:10kg 25kg 200 kilograms per barrel Remarks:good
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:BC-1215
CAS:1507370-20-8
Purity:98% Package:5mg Remarks:V32687
Company Name: Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel: +86-057181025280; +8617767106207
Email: sales@molcore.com
Products Intro: Product Name:N1,N2-bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine
CAS:1507370-20-8
Purity:95%+ Remarks:MC714357
N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine Basic information
Product Name:N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine
Synonyms:BC-1215;N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine;BC-1215 (BC 1215;1,2-Ethanediamine, N1,N2-bis[[4-(2-pyridinyl)phenyl]methyl]-;BC-1215 >=98% (HPLC);{[4-(pyridin-2-yl)phenyl]methyl}[2-({[4-(pyridin-2-yl)phenyl]methyl}amino)ethyl]amine;N1,N2-bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine;Ligands for E3 Ligase,E3 ligase-recruiting Moiety,F-box protein 3 (Fbxo3),Inhibitor,inhibit,inflammation,MLE cells,BC 1215,PBMC cells,BC-1215,BC1215,U937 cells,TRAF
CAS:1507370-20-8
MF:C26H26N4
MW:394.51
EINECS:
Product Categories:
Mol File:1507370-20-8.mol
N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine Structure
N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine Chemical Properties
Boiling point 589.9±50.0 °C(Predicted)
density 1.125±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,2-8°C
solubility DMSO: soluble2mg/mL, clear (warmed)
pka9.05±0.20(Predicted)
form A crystalline solid
color white to beige
InChIInChI=1S/C26H26N4/c1-3-15-29-25(5-1)23-11-7-21(8-12-23)19-27-17-18-28-20-22-9-13-24(14-10-22)26-6-2-4-16-30-26/h1-16,27-28H,17-20H2
InChIKeyIXEPQJQQSLMESJ-UHFFFAOYSA-N
SMILESC(NCC1=CC=C(C2=NC=CC=C2)C=C1)CNCC1=CC=C(C2=NC=CC=C2)C=C1
Safety Information
Hazard Codes Xn
Risk Statements 22
MSDS Information
N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine Usage And Synthesis
DescriptionBC-1215 (N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine) is an inhibitor of F-box protein 3 (FBXO3; IC50 = 0.9 μg/mL for Il-1β release). It decreases FBXO3 interaction with F-box/LRR-repeat protein 2 (FBXL2) in a dose-dependent manner and prevents FBXO3-dependent ubiquitination of FBXL2. It also lowers expression of Tnf receptor-associated factors (TRAFs) 1-6 without affecting TRAF1-6 mRNA levels in resting and LPS-stimulated peripheral blood mononuclear cells (PBMCs). BC-1215 (100 μg, i.p., per animal) reduces plasma levels of the inflammatory cytokines Il-6, Tnf, and Il-1β and decreases peritoneal bacteria counts in a mouse model of cecal ligation and puncture-induced sepsis. It also reduces inflammation in mouse models of DSS-induced colitis, paw edema, and ear edema.
N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine Preparation Products And Raw materials
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