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1,2,3-1H-Triazole

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1,2,3-1H-Triazole Basic information
Description
Product Name:1,2,3-1H-Triazole
Synonyms:1,2,3-1H-Triazole,97%;3-Triazole;2,3-Diazapyrrole;v-Triazole (7CI,8CI);1H,2H-<1,2,3>TriazoliuMyl-(5)-Zwitterion;1,2,3-Triazole, 97+%;1H-1,2,3-Triazole;LABOTEST-BB LT02056574
CAS:288-36-8
MF:C2H3N3
MW:69.07
EINECS:608-262-3
Product Categories:Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Building Blocks;Heterocyclic Building Blocks;Triazoles;bc0001
Mol File:288-36-8.mol
1,2,3-1H-Triazole Structure
1,2,3-1H-Triazole Chemical Properties
Melting point 23-25 °C(lit.)
Boiling point 203 °C752 mm Hg(lit.)
density 1.192 g/mL at 25 °C(lit.)
refractive index n20/D 1.498(lit.)
Fp 225 °F
storage temp. Sealed in dry,Room Temperature
solubility Acetone, Chloroform, Methanol (Slightly)
form Liquid
pka1.17(at 20℃)
color Clear colorless to yellow
Specific Gravity1.192
Water Solubility soluble
FreezingPoint 21.0 to 24.0 ℃
BRN 104766
InChIKeyQWENRTYMTSOGBR-UHFFFAOYSA-N
CAS DataBase Reference288-36-8(CAS DataBase Reference)
NIST Chemistry Reference1H-1,2,3-Triazole(288-36-8)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-63-36-22
Safety Statements 37/39-26-36/37
WGK Germany 3
Hazard Note Irritant
HS Code 29339900
MSDS Information
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SigmaAldrich English
ACROS English
ALFA English
1,2,3-1H-Triazole Usage And Synthesis
Description1,2,3-1H-Triazole is a kind of azole compound. It can effectively promote the proton conduction in polymer electrolyte membranes via an intermolecular proton-transfer mechanism. It is also a useful triazole for proteomics research1. It also find use in research as a bioisostere in medicinal chemistry as well as an building block for more complex chemical compounds, including pharmaceutical drugs such as mubritinib and tazobactam2. It is a main class of hetero-cycles because of its extensive range of biological properties such as antimicrobial, anticancer, anti-tubercular, anti-HIV, antimalarial, antibacterial, antifungal, antiviral and anti-diabetic property3.
Chemical Propertiesclear colorless liquid
UsesIt effectively promotes the proton conduction in polymer electrolyte membranes via an intermolecular proton-transfer mechanism. A useful triazole for proteomics research
UsesA basic 5-membered aromatic heterocycle used as a building block for more complex pharmaceutical compounds. There have been recent studies that showed antitumor, antiinflammatory, analgesic, antifunga l, antibacterial and antiviral activities in bioactive triazoles.
DefinitionChEBI: 1H-1,2,3-triazole is a 1,2,3-triazole. It is a tautomer of a 2H-1,2,3-triazole and a 4H-1,2,3-triazole.
Synthesis Reference(s)The Journal of Organic Chemistry, 62, p. 9177, 1997 DOI: 10.1021/jo971313o
General Description2H-1,2,3-triazole is tautomeric form of 1H-1,2,3-triazole. 1H-1,2,3-triazole effectively promotes the proton conduction in polymer electrolyte membranes via an intermolecular proton-transfer mechanism.
Tag:1,2,3-1H-Triazole(288-36-8) Related Product Information
1H-Benzotriazole 3-Amino-1,2,4-Triazole 5-Methyl-1H-benzotriazole 1,2,4-Triazole Tolyltriazole Tazobactam acid TBTA BENZHYDRYL 6,6-DIHYDROPENICILLIC ACID 1-OXIDE[TAZOBACTAM INTERMEDIATE] Benzophenone hydrazone Tazobactam Acid Impurity 16 Tazobactam Impurity B Tazobactam Impurity 5 Tazobactam Acid Impurity 14 Tazobactam Acid Impurity 12 Tazobactam Diphenylmethyl Ester (2S,5R)-3α-Chloromethyl-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2β-carboxylic acid benzhydryl ester 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-bromo-3,3-dimethyl-7-oxo-, diphenylmethyl ester, 4-oxide, (2S,5R,6S)- [2S-(2alpha,5alpha,6alpha)]-6-bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid