|
| 5-Fluoro-2-methylindole Basic information |
| 5-Fluoro-2-methylindole Chemical Properties |
Melting point | 98-101 °C (lit.) | Boiling point | 112-120C | density | 1.219±0.06 g/cm3(Predicted) | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | pka | 16.73±0.30(Predicted) | form | Solid | color | Light yellow to Brown | InChI | InChI=1S/C9H8FN/c1-6-4-7-5-8(10)2-3-9(7)11-6/h2-5,11H,1H3 | InChIKey | JJIUISYYTFDATN-UHFFFAOYSA-N | SMILES | N1C2=C(C=C(F)C=C2)C=C1C | CAS DataBase Reference | 399-72-4(CAS DataBase Reference) |
| 5-Fluoro-2-methylindole Usage And Synthesis |
Description | 5-Fluoro-2-methylindole is a chemical intermediate that can be used in the synthesis of other compounds. It is a versatile building block with many applications, such as being a useful intermediate for the synthesis of heterocyclic compounds. This compound reacts with aniline to form 2,6-diaminopyridine, which has been shown to have anti-inflammatory properties. | General Description | 5-Fluoro-2-methylindole (5-Fluoro-2-methyl-1H-indole) is a 5-substituted-2-methyl-1H-indole. | Synthesis | 1-(5-fluoro-2-nitrophenyl) propane-2-one (0.5mmol, 99 mg), zinc powder (3.0mmol, 196 mg), and acetic acid (6.0mmol, 360 mg) was added to the reaction tube, followed by adding ethanol to 2 ml at 90 °C for 3h. After cooling to room temperature, the reaction system was added 20 ml water. 5-Fluoro-2-methylindole was obtained after purification. | Solubility in water | Very soluble in N,N-Dimethylformamide,Soluble in methanol,Sparingly soluble inglacial acetic acid, Very slightly soluble inchloroform, Practically insoluble in water. |
| 5-Fluoro-2-methylindole Preparation Products And Raw materials |
|