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Ketoprofen Suppliers list
Company Name: Baoji Guokang Bio-Technology Co., Ltd.
Tel: 0917-3909592 13892490616
Products Intro: Product Name:Ketoprofen
Purity:0.99 Package:25KG;10KG;5KG;1KG
Company Name: Shanghai Bojing Chemical Co.,Ltd.
Tel: +86-21-37122233 +86-13795318958
Products Intro: Product Name:Ketoprofen
Purity:99% Package:1Kg;25kg/ Drum or as customer request
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Products Intro: CAS:22071-15-4
Purity:99% Package:25KG;5KG;1KG
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: +8615858145714
Products Intro: Product Name:Ketoprofen
Purity:as in COA Package:as customers' requirements
Company Name: Guangzhou PI PI Biotech Inc
Tel: +8618371201331
Products Intro: Product Name:Ketoprofen
Purity:90%+ Package:10mg, 25mg, 50mg, 100mg, Other scale please email Remarks:(2RS)-2-(3-Benzoylphenyl)propanoic acid

Ketoprofen manufacturers

  • Ketoprofen
  • $0.00 / 1KG
  • 2022-06-02
  • CAS:22071-15-4
  • Min. Order: 0.01KG
  • Purity: 99%
  • Supply Ability: 1 tons
  • ketoprofen
  • $100.00 / 1bag
  • 2022-03-04
  • CAS:22071-15-4
  • Min. Order: 1bag
  • Purity: 99
  • Supply Ability: 500
  • Ketoprofen
  • $60.00 / 1KG
  • 2022-02-25
  • CAS:22071-15-4
  • Min. Order: 10KG
  • Purity: 99%
  • Supply Ability: 1000kg

Related articles

  • The Pharmacology of ketoprofen
  • Ketoprofen (3-benzoyl-α-methylphenylacetic acid) is a 2-arylpropionic acid potent non-steroidal anti-inflammatory drug.
  • Apr 8,2022
Ketoprofen Basic information
Used in Particular Diseases
Product Name:Ketoprofen
Synonyms:RARECHEM AL BO 1306;M-BENZOYLHYDRATROPIC ACID;2-(meta-benzoylphenyl) propionic acid;19583 RP;19583rp;2-(3-benzoylphenyl)-propionicaci;2-(m-Benzoylphenyl)propionic acid;2-(m-benzoylphenyl)propionicacid
Product Categories:ACTRON;Other APIs;Lipid signaling;Pharmaceutical raw material;API;Analgesics;Pharmaceutical;Active Pharmaceutical Ingredients;APIs;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical ingredients
Mol File:22071-15-4.mol
Ketoprofen Structure
Ketoprofen Chemical Properties
Melting point 93-96°C
Boiling point 357.5°C (rough estimate)
density 1.1565 (rough estimate)
refractive index 1.5600 (estimate)
storage temp. 2-8°C
solubility Slightly soluble in chloroform and methanol.
pkapKa 5.94(MeOH/H2O) (Uncertain)
form solid
color White to Off-White
Water Solubility 209mg/L(room temperature)
Merck 14,5305
CAS DataBase Reference22071-15-4(CAS DataBase Reference)
NIST Chemistry ReferenceKetoprofen(22071-15-4)
EPA Substance Registry SystemBenzeneacetic acid, 3-benzoyl-.alpha.-methyl- (22071-15-4)
Safety Information
Hazard Codes T
Risk Statements 25-36/37/38-23/24/25
Safety Statements 26-45-36/37/39
WGK Germany 3
RTECS UE7570000
HazardClass 6.1(b)
PackingGroup III
HS Code 29183000
ToxicityLD50 orally in rats: 101 mg/kg (Ueno)
MSDS Information
2-(3-Benzoylphenyl)propionic acid English
Ketoprofen Usage And Synthesis
Used in Particular DiseasesAcute Gouty Arthritis:
Dosage and Frequency: 75 mg four times a day
DescriptionKetoprofen is a chemical that comes in the form of a white crystalline powder; odorless or nearly odorless. It is very soluble in methanol, soluble in ethanol, acetone or ether, and almost insoluble in water. The melting point is about 93-96 °C. For the arylalkanoic acid compounds. Has analgesic, anti-inflammatory and antipyretic effects. The anti-inflammatory effect is stronger than that of ibuprofen, with less side effects and low toxicity. Oral and easily absorbed from the gastrointestinal tract. After 1 administration, the peak plasma concentration can be reached in about 0.5 to 2 hours. t 1/2 is 1.6 to 1.9 hours. In the blood and plasma protein binding force is extremely strong. The excretion rate from urine is 30% to 90% within 24 hours. Mainly excreted in the form of glucuronic acid conjugates. For rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and gout, etc.
DescriptionKetoprofen (3-benzoyl-α-methylphenylacetic acid) is a 2-arylpropionic acid potent non-steroidal anti-inflammatory drug. It was first synthesized by French chemist Rhone Poulenc in 1967. In 1973, it was introduced into France and the United States as an anti-inflammatory drug. It has good effects on rheumatism, rheumatoid arthritis, myelitis and gout, and its anti-inflammatory effect is stronger than that of ibuprofen. Ibuprofen. At the same dose, its anti-inflammatory and analgesic effect is 150 times that of aspirin, its antipyretic effect is 4 times that of indomethacin and 100 times that of aspirin. Because ketoprofen has high efficacy, short half-life, It has the advantages of simple metabolism and few and mild adverse reactions, and has been widely used in the treatment of various types of pain, inflammatory symptoms, colds and post-operative anti-inflammatory analgesia.
Chemical PropertiesWhite Crystalline Solid
UsesNatural Vitamin B12. analog
UsesAnti-inflammatory; analgesic
UsesKetoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.
IndicationsKetoprofen (Orudis) is indicated for use in rheumatoid and osteoarthritis, for mild to moderate pain, and in dysmenorrhea. The most frequently reported side effects are GI (dyspepsia, nausea, abdominal pain, diarrhea, constipation, and flatulence) and CNS related (headache, excitation). Edema and increased blood urea nitrogen have also been noted in more than 3% of patients. Ketoprofen can cause fluid retention and increases in plasma creatinine, particularly in the elderly and in patients taking diuretics.
DefinitionChEBI: An oxo monocarboxylic acid that consists of propionic acid substituted by a 3-benzoylphenyl group at position 2.
Manufacturing ProcessIn an initial step, the sodium derivative of ethyl (3-benzoylphenyl) cyanoacetate is prepared as follows: (3-benzoylphenyl)acetonitrile (170 9) is dissolved in ethyl carbonate (900 g). There is added, over a period of 2 hours, a sodium ethoxide solution [prepared from sodium (17.7 g) and anhydrous ethanol (400 cc)], the reaction mixture being heated at about 105° to 115°C and ethanol being continuously distilled. A product precipitates. Toluene (500 cc) is added, and then, after distillation of 50 cc of toluene, the product is allowed to cool. Diethyl ether (600 cc) is added and the mixture is stirred for 1 hour. The crystals which form are filtered off and washed with diethyl ether (600 cc) to give the sodium derivative of ethyl (3-benzoylphenyl)cyanoacetate (131 g).
Then, ethyl methyl(3-benzoylphenyl)cyanoacetate employed as an intermediate material is prepared as follows: The sodium derivative of ethyl (3-benzoylphenyl)cyanoacetate (131 g) is dissolved in anhydrous ethanol (2 liters). Methyl iodide (236 g) is added and the mixture is heated under reflux for 22 hours, and then concentrated to dryness under reduced pressure (10 mm Hg). The residue is taken up in methylene chloride (900 cc) and water (500 cc) and acidified with 4N hydrochloric acid (10 cc). The methylene chloride solution is decanted, washed with water (400 cc) and dried over anhydrous sodium sulfate. The methylene chloride solution is filtered through a column containing alumina (1,500 g). Elution is effected with methylene chloride (6 liters), and the solvent is evaporated under reduced pressure (10 mm Hg) to give ethyl methyl(3-benzoylphenyl)cyanoacetate (48 g) in the form of an oil.
In the final production preparation, a mixture of ethyl methyl(3- benzoylphenyl)cyanoacetate (48 g), concentrated sulfuric acid (125 cc) and water (125 cc) is heated under reflux under nitrogen for 4 hours, and water (180 cc) is then added. The reaction mixture is extracted with diethyl ether (300 cc) and the ethereal solution is extracted with N sodium hydroxide (300 cc). The alkaline solution is treated with decolorizing charcoal (2 g) and then acidified with concentrated hydrochloric acid (40 cc). An oil separates out, which is extracted with methylene chloride (450 cc), washed with water (100 cc) and dried over anhydrous sodium sulfate. The product is concentrated to dryness under reduced pressure (20 mm Hg) to give a brown oil (33.8 g).
This oil is dissolved in benzene (100 cc) and chromatographed through silica (430 g). After elution with ethyl acetate, there is collected a fraction of 21 liters, which is concentrated to dryness under reduced pressure (20 mm Hg). The crystalline residue (32.5 g) is recrystallized from acetonitrile (100 cc) and a product (16.4 g), MP 94°C, is obtained. On recrystallization from a mixture of benzene (60 cc) and petroleum ether (200 cc), there is finally obtained 2- (3-benzoylphenyl)propionic acid (13.5 g), MP 94°C.
Brand nameActron (Bayer); Orudis (Wyeth); Oruvail (Wyeth).
Therapeutic FunctionAntiinflammatory
General DescriptionKetoprofen (Orudis, Rhodis) and suprofen (Profenal) areclosely related to fenoprofen in their structures, properties,and indications. Even though ketoprofen has been approvedfor OTC use (Orudis KT, Actron), its GI side effects aresimilar to indomethacin, and therefore its useshould be closely monitored, especially in patients with GIor renal problems.
Contact allergensKetoprofen is an anti-inflammatory drug, used both topically and systemically. It is above all a photoaller- gen, responsible for photoallergic or photo-worsened contact dermatitis, with sun-induced, progressive, severe, and durable reactions. Recurrent photosensitiv- ity is possible for many years. Photosensitivities are expected to thiophene-phenylketone derivatives such as tiaprofenic acid and suprofen, to ketoprofen esters such as piketoprofen, and to benzophenone derivatives (see above) such as fenofibrate and benzophenone-3. Concomitant photosensitivities without clinical rel- evance have been observed to fenticlor, tetrachloro- salicylanilide, triclosan, tribromsalan, and bithionol.
Biochem/physiol ActionsIt serves as an efficient drug to treat ankylosing spondylitis, rheumatoid arthritis and osteoarthritis. It also has antipyretic and analgesic effects. Ketoprofen prevents the action of prostaglandin synthetase.
PharmacokineticsKetoprofen is rapidly and nearly completely absorbed on oral administration, reaching peak plasma levels within 0.5 to 2 hours. It is highly plasma protein bound (99%) despite a lower acidity (pKa = 5.9) than some other NSAIDs. Wide variation in plasma half-lives has been reported. It is metabolized by glucuronidation of the carboxylic acid, CYP3A4 and CYP2C9 hydroxylation of the benzoyl ring, and reduction of the keto function.
Clinical UseKetoprofen, unlike many NSAIDs, inhibits the synthesis of leukotrienes and leukocyte migration into inflamed joints in addition to inhibiting the biosynthesis of prostaglandins. It stabilizes the lysosomal membrane during inflammation, resulting in decreased tissue destruction. Antibradykinin activity also has been observed. Bradykinin is released during inflammation and can activate peripheral pain receptors. In addition to anti-inflammatory activity, ketoprofen also possesses antipyretic and analgetic properties. Although it is less potent than indomethacin as an anti-inflammatory agent and an analgetic, its ability to produce gastric lesions is about the same.
Safety ProfilePoison by ingestion,subcutaneous, intravenous, rectal, and intraperitoneal routes. Human systemic effects by an unspecified route:headache, nausea or vomiting, and degenerative changesin the brain, changes in kidney tubules. An experimentalteratogen.
Chemical SynthesisKetoprofen, 2-(3-benzoyl)propionic acid (3.2.37), is synthesized from 3-methylbenzophenone, which undergoes bromination and forms 3-bromo-methylbenzophenone (3.2.33). The reduction of the resulting product by sodium cyanide gives 3-cyanomethylbenzophenone (3.2.34), which is reacted with the diethyl ester of carbonic acid in the presence of sodium ethoxide. The resulting cyanoacetic ester derivative (3.2.25) is alkylated by methyl iodide and the resulting product (3.2.36) undergoes acidic hydrolysis, forming ketoprofen (3.2.37) [104–106].

Veterinary Drugs and TreatmentsKetoprofen is labeled for use in horses for the alleviation of inflammation and pain associated with musculoskeletal disorders. Like flunixin (and other NSAIDs), ketoprofen potentially has many other uses in a variety of species and conditions. There are approved dosage forms for dogs and cats in Europe and Canada. Some consider ketoprofen to be the NSAID of choice for use short-term for analgesia in cats.
Drug interactionsConcomitant use of alcohol or other NSAIDs after taking ketoprofen can increase gastrointestinal side effects and may cause ulcers. When ketoprofen is used together with aspirin or other salicylic acid drugs, the efficacy cannot be increased, but the incidence of gastrointestinal side effects and bleeding tendency increases. Concomitant use of ketoprofen with anticoagulants increases the risk of bleeding. Ketoprofen can enhance the effect of antidiabetic drugs and reduce the antihypertensive effect of antihypertensive drugs; ketoprofen and corticosteroids can be used together, which can significantly reduce the symptoms of inflammation. Ketoprofen should not be used with methotrexate to prevent poisoning. When ketoprofen is used with probenecid, verapamil, and nifedipine, the dose should be reduced; when ketoprofen is used with digoxin, the dose of digoxin should be adjusted.
MetabolismTwo processes are involved in the biotransformation of ketoprofen: one very minor (hydroxylation), and the other largely predominant (conjugation with glucuronic acid). Less than 1% of the dose of ketoprofen administered is recovered in unchanged form in the urine, whereas the glucuronide metabolite accounts for about 65-75%. The drug is excreted as metabolites essentially by the urinary route. The rate of excretion is rapid, since 50% of the dose administered is eliminated in the first 6 hours.
Ketoprofen Preparation Products And Raw materials
Raw materialsSulfuric acid-->Iodomethane-->3-Benzoylphenylacetonitrile-->Sodium-->Ethanol-->3-BENZOYLPHENYLACETIC ACID
Preparation ProductsPhthalide-->3-ACETYLBENZOIC ACID
Tag:Ketoprofen(22071-15-4) Related Product Information
Desmethyl Ketoprofen (S)-(+)-Ketoprofen KETOPROFEN TROMETHAMINE AMIDE 3-(CYANOMETHYL)BENZOIC ACID 3-ACETYLBENZOPHENONE QISHTWCSIVFJBU-UHFFFAOYSA-N Ketoprofen Impurity 15 Benzeneacetic acid, 3-benzoyl-a-Methyl-, ethyl ester 3-Benzoylphenylacetonitrile 3-(1-cyanoethyl)benzoic acid (intermediate of ketoprofen) Ketoprofen-d3 Methyl Ester Dihydro Ketoprofen (Mixture of Diastereomers) Dihydro Ketoprofen-13C,d3 (Mixture of Diastereomers) rac-Ketoprofen-13CD3,Ketoprofen-13CD3 Ketoprofen lysine salt,Lysyl-ketoprofen,ketoprofen lysine KETOPROFEN-D3 KETOPROFEN SR PELLET rac Ketoprofen Glucuronide Allyl Ester,dl-Ketoprofen Glucuronide Allyl Ester,Ketoprofen Allyl Glucuronate