- 2-Nitro-1-naphthol
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- $200.00 / 1KG
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2024-01-02
- CAS:607-24-9
- Min. Order: 1KG
- Purity: 99%, 99.5% Sublimated
- Supply Ability: g-kg-tons, free sample is available
- 2-Nitro-1-naphthol
-
- $0.00 / 1KG
-
2022-09-29
- CAS:607-24-9
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1ton
- 2-Nitro-1-naphthol
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- $0.00 / 1KG
-
2022-02-22
- CAS:607-24-9
- Min. Order: 1KG
- Purity: 97.4%
- Supply Ability: 100 tons
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| | 2-Nitro-1-naphthol Basic information |
| | 2-Nitro-1-naphthol Chemical Properties |
| Melting point | 123-125 °C (lit.) | | Boiling point | 324.41°C (rough estimate) | | density | 1.3175 (rough estimate) | | refractive index | 1.5400 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | pka | 6.13±0.50(Predicted) | | form | Powder | | InChI | InChI=1S/C10H7NO3/c12-10-8-4-2-1-3-7(8)5-6-9(10)11(13)14/h1-6,12H | | InChIKey | MUCCHGOWMZTLHK-UHFFFAOYSA-N | | SMILES | C1(O)=C2C(C=CC=C2)=CC=C1[N+]([O-])=O | | CAS DataBase Reference | 607-24-9(CAS DataBase Reference) | | NIST Chemistry Reference | 2-Nitro-1-naphthol(607-24-9) |
| | 2-Nitro-1-naphthol Usage And Synthesis |
| Description | 2-Nitro-1-naphthol is an important organic compound with anti-inflammatory properties used as an analytical method for measuring albumin concentration and as an enzyme-labelled substrate in electrochemical immunoassays. The substance reacts with albumin to form a coloured complex which can be detected spectrophotometrically. It is also used as a model system for the study of inflammatory diseases and inhibits p38 kinase activity. In addition, a derivative of 2-Nitro-1-naphthol (4-nitro-1-naphthol) can be used to prepare chromogenic substrates for neutral or slightly acidic hydrolases. | | Chemical Properties | yellow-green to ochre-brown powder and/or chunks | | Uses | 2-Nitro-1-naphthol was employed as substrate for use in an amperometric 3-electrode system for the determination of alkaline phosphatase, the enzyme label most commonly used in electrochemical immunoassays. It was also used in the preparation of:
- di-(2-nitro-1-naphthyl) hydrogen phosphate
- 1-(2′-methyl-3′-indenyl)-2-naphthylamine and -2-naphthol (axially chiral ligands)
| | Application | 2-Nitro-1-naphthol is commonly used as an intermediate in organic synthesis. It is a derivative of 1-nitro-2-naphthol and 4-nitro-1-naphthol. 1-Nitro-2-naphthol has been found to be a potent inhibitor of enzyme-dependent activation of acetyl-CoA, while 4-nitro-1-naphthol facilitates the preparation of chromogenic substrates for neutral or slightly acidic hydrolases[1-2]. | | Purification Methods | Crystallise the naphthol (repeatedly) from EtOH. [Beilstein 6 H 615, 6 III 2938, 6 IV 4236.] | | References | [1] JIZHENG DANG . Chromogenic substrate from 4-nitro-1-naphthol for hydrolytic enzyme of neutral or slightly acidic optimum pH: 4-Nitro-1-naphthyl-β-d-galactopyranoside as an example[J]. Bioorganic & Medicinal Chemistry Letters, 2013. DOI:10.1016/j.bmcl.2012.11.120.
[2] ATSUKO SHINOHARA. Inhibition of acetyl-coenzyme A dependent activation of N-hydroxyarylamines by phenolic compounds, pentachlorophenol and 1-nitro-2-naphthol[J]. Chemico-Biological Interactions, 1986. DOI:10.1016/0009-2797(86)90058-X.
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| | 2-Nitro-1-naphthol Preparation Products And Raw materials |
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