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2'-Azido-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine manufacturers
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| | 2'-Azido-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine Basic information |
| Product Name: | 2'-Azido-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine | | Synonyms: | 2'-Azido-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine;2'-Azido-2'-deoxy-5'-O-DMT-uridine;2’-Azido-2’-deoxy-5’-O-(4,4’-dimethoxytrityl)uridine;2'-azido-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine;2’-Azido-2’-deoxy-5’-O-DMTr-uridine | | CAS: | 177980-10-8 | | MF: | C30H29N5O7 | | MW: | 571.59 | | EINECS: | | | Product Categories: | | | Mol File: | 177980-10-8.mol |  |
| | 2'-Azido-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine Chemical Properties |
| | 2'-Azido-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine Usage And Synthesis |
| Uses | 2′-Azido-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 2′-Azido-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | References | [1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005 |
| | 2'-Azido-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine Preparation Products And Raw materials |
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