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Beijing Ouhe Technology Co., Ltd
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Product Name:Gly-β-MCA
CAS:66225-78-3
Purity:98% Package:100mg
|
2-((4R)-4-((3R,5R,6S,7R,10R,13R)-3,6,7-Trihydroxy-10,13-Dimethylhexadecahydro-1H-Cyclopenta[A]Phenanthren-17-Yl)Pentanamido)Acetic Acid manufacturers
- Gly-β-MCA
-
- $199.00 / 1mg
-
2025-11-05
- CAS:66225-78-3
- Min. Order:
- Purity: ≥98.0%
- Supply Ability: 10g
- Gly-β-MCA
-
- $199.00 / 1mg
-
2025-11-05
- CAS:66225-78-3
- Min. Order:
- Purity: ≥98.0%
- Supply Ability: 10g
|
| | 2-((4R)-4-((3R,5R,6S,7R,10R,13R)-3,6,7-Trihydroxy-10,13-Dimethylhexadecahydro-1H-Cyclopenta[A]Phenanthren-17-Yl)Pentanamido)Acetic Acid Basic information |
| Product Name: | 2-((4R)-4-((3R,5R,6S,7R,10R,13R)-3,6,7-Trihydroxy-10,13-Dimethylhexadecahydro-1H-Cyclopenta[A]Phenanthren-17-Yl)Pentanamido)Acetic Acid | | Synonyms: | 2-((4R)-4-((3R,5R,6S,7R,10R,13R)-3,6,7-Trihydroxy-10,13-Dimethylhexadecahydro-1H-Cyclopenta[A]Phenanthren-17-Yl)Pentanamido)Acetic Acid;2-((4R)-4-((3R,5R,6S,7R,10R,13R)-3,6,7-Trihydroxy-10,13-Dimethylhexadecahydro-1H-Cyclopenta[A]Phenanthren-17-Yl)Pentanamido)Acetic Acid(WXC04817);Glycine--Muricholic Acid;N-[(3α,5β,6β,7β)-3,6,7-Trihydroxy-24-oxocholan-24-yl]glycine;Glyco-?-Muricholic Acid;Glycine-β-muricholic acid (GβMCA);Gly-β-MCA;Glycine-β-muricholic Acid | | CAS: | 66225-78-3 | | MF: | C26H43NO6 | | MW: | 465.62 | | EINECS: | | | Product Categories: | | | Mol File: | 66225-78-3.mol | ![2-((4R)-4-((3R,5R,6S,7R,10R,13R)-3,6,7-Trihydroxy-10,13-Dimethylhexadecahydro-1H-Cyclopenta[A]Phenanthren-17-Yl)Pentanamido)Acetic Acid Structure](CAS/20200119/GIF/66225-78-3.gif) |
| | 2-((4R)-4-((3R,5R,6S,7R,10R,13R)-3,6,7-Trihydroxy-10,13-Dimethylhexadecahydro-1H-Cyclopenta[A]Phenanthren-17-Yl)Pentanamido)Acetic Acid Chemical Properties |
| Boiling point | 673.4±55.0 °C(Predicted) | | density | 1.213±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml | | form | A crystalline solid | | pka | 3.58±0.10(Predicted) | | color | White to off-white |
| | 2-((4R)-4-((3R,5R,6S,7R,10R,13R)-3,6,7-Trihydroxy-10,13-Dimethylhexadecahydro-1H-Cyclopenta[A]Phenanthren-17-Yl)Pentanamido)Acetic Acid Usage And Synthesis |
| Uses | Gly-β-MCA, a bile acid, is a potent, sable, intestine-selective and oral bioactive farnesoid X receptor (FXR) inhibitor that may be a candidate for the treatment of metabolic disorders[1]. | | in vivo | Gly-β-MCA (Gly-MCA, p.o. 10 and 50 mg/kg) prevents and treats diet-induced and genetic obesity, along with insulin resistance and hepatic steatosis without systemic, hepatic or intestinal toxicities in mice[1].
Gly-MCA does not increase faecal LCN-2 levels, indicating that Gly-MCA does not induce intestinal inflammation[1]. | | storage | Store at -20°C | | References | [1] Jiang C, et al. Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction. Nat Commun. 2015 Dec 15;6:10166. DOI:10.1038/ncomms10166 |
| | 2-((4R)-4-((3R,5R,6S,7R,10R,13R)-3,6,7-Trihydroxy-10,13-Dimethylhexadecahydro-1H-Cyclopenta[A]Phenanthren-17-Yl)Pentanamido)Acetic Acid Preparation Products And Raw materials |
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