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MedChemexpress LLC
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Product Name:MP-A08
CAS:219832-49-2
Purity:>98% Package:1500RMB/1mg
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| Product Name: | MP-A08 | | Synonyms: | MP-A08;Benzenesulfonamide, 4-methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]-;4-Methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]benzenesulfonamide;4-Methyl-N-(2-((2-((4-methylphenyl)sulfonamido)benzylidene)amino)phenyl)benzenesulfonamide;MPA08,SphK,Sphingosine kinase,MP-A-08,inhibit,Inhibitor,MP-A08,MP A08 | | CAS: | 219832-49-2 | | MF: | C27H25N3O4S2 | | MW: | 519.64 | | EINECS: | | | Product Categories: | | | Mol File: | 219832-49-2.mol |  |
| | MP-A08 Chemical Properties |
| Boiling point | 717.1±70.0 °C(Predicted) | | density | 1.28±0.1 g/cm3(Predicted) | | solubility | DMF: 33 mg/ml; DMF:PBS(pH7.2) (1:2): 0.3 mg/ml; DMSO: 12 mg/ml | | form | A crystalline solid | | pka | 7.88±0.10(Predicted) |
| | MP-A08 Usage And Synthesis |
| Description | MP-A08 is an ATP-competitive inhibitor of sphingosine kinases SPHK1 and SPHK2 (Kis = 27 and 6.9 μM, respectively). It is selective for SPHK1/2 over a panel of 140 human protein kinases at concentrations up to 25 μM. MP-A08 (15 μM) reduces generation of cellular sphingosine-1-phosphate (S1P; ) without inducing degradation of SPHK1 in Jurkat cells. It induces a 3.7-, 3.5-, and 5.8-fold increase in C-18 ceramide , C-20 ceramide , and C20:1-ceramide levels, respectively, and dose-dependently activates the apoptosis-associated p38 and JNK pathways in vitro. MP-A08 reduces proliferation of a variety of human cancer cell lines (EC50s = 8-44.9 μM). MP-A08 also reduces tumor vasculature, as determined by CD31 staining, and volume as well as S1P protein levels in A549 human lung adenocarcinoma xenografts in mice. | | Uses | NSC 122314 is selective ATP competitive sphingosine kinase 2 and 1 inhibitor. Also it induces mitochondrial-associated apoptosis. | | Definition | ChEBI: MP-A08 is a sulfonamide that consists of two moieties of 4-methyl-N-phenylbenzenesulfonamide connected to each other at position 2 by an aldimine linker. It is a ATP-competitive inhibitor of sphingosine kinase that targets both SK1 and SK2 (Ki values of 27 muM and 6.9 muM, respectively) and exhibits anti-cancer properties. It has a role as an antineoplastic agent, an apoptosis inducer, an angiogenesis inhibitor and an EC 2.7.1.91 (sphingosine kinase) inhibitor. It is a sulfonamide, a member of toluenes and an aldimine. | | storage | Store at -20°C |
| | MP-A08 Preparation Products And Raw materials |
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