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(S)-CR8

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(S)-CR8 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: CAS:1084893-56-0
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:(S)-CR8；(S) CR8;(S)CR8
CAS:1084893-56-0
Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Aladdin Scientific
Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:(S)-CR8
CAS:1084893-56-0
Purity:>=98% Package:$71.9/1mg;$199.9/5mg;Bulk package Remarks:98%
Company Name: Hubei Chuangliankangcheng Pharmaceutical Co., Ltd.  
Tel: 027-65388397 18164111589
Email: 3321478047@qq.com
Products Intro: Product Name:(S)-CR8
CAS:1084893-56-0
Purity:97% Package:1g;10g
Company Name: ATK CHEMICAL COMPANY LIMITED  
Tel: 3429815786 13301662590
Email: sales@atkchemical.com
Products Intro: CAS:1084893-56-0
Purity:98% HPLC Package:1G;5G;10G;25G;50G;100G,1KG;25KG;50KG
(S)-CR8 Basic information
Product Name:(S)-CR8
Synonyms:CR8, (S)-Isomer - CAS 1084893-56-0 - Calbiochem;1-Butanol, 2-[[9-(1-methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-, (2S)-;CR8, (S)-Isomer
CAS:1084893-56-0
MF:C24H29N7O
MW:431.53
EINECS:
Product Categories:
Mol File:1084893-56-0.mol
(S)-CR8 Structure
(S)-CR8 Chemical Properties
Boiling point 671.4±65.0 °C(Predicted)
density 1.27±0.1 g/cm3(Predicted)
storage temp. +2C to +8C
solubility DMSO: soluble,Ethanol: soluble
form Off-white solid
pka14.56±0.10(Predicted)
Safety Information
MSDS Information
(S)-CR8 Usage And Synthesis
Description(S)-CR8 is a second generation derivative of (R)-roscovitine and an inhibitor of cyclin-dependent kinase 1 (Cdk1/cyclin B), Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and Cdk9/cyclin T (IC50s = 0.15, 0.08, 0.06, 0.12, and 0.11 μM, respectively). It also inhibits casein kinase CK1δ/ε (CKδ/ε) and DYRK1A (IC50s = 0.61 and 0.9 μM, respectively). (S)-CR8 reduces cell viability in human neuroblastoma cell lines, including SH-SY5Y, SK-N-AS, SK-N-BE, and IMR32 cells (IC50s = 0.43, 1.46, 0.13, and 0.14 μM, respectively). It also reduces protein levels of the survival factor Mcl-1 in SH-SY5Y cells.
DefinitionChEBI: (2S)-2-[[9-propan-2-yl-6-[[4-(2-pyridinyl)phenyl]methylamino]-2-purinyl]amino]-1-butanol is a phenylpyridine.
(S)-CR8 Preparation Products And Raw materials
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