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Product Name:Desmethyl-YM 298198
CAS:1177767-57-5
Purity:≥98% by HPLC Remarks:Desmethyl-YM 298198 is a derivative of YM 298198, a selective antagonist of mGlu1.
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Desmethyl YM 298198 hydrochloride manufacturers
- Desmethyl-YM 298198
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- $2500.00 / 100mg
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2025-07-16
- CAS:1177767-57-5
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | Desmethyl YM 298198 hydrochloride Basic information |
| | Desmethyl YM 298198 hydrochloride Chemical Properties |
| storage temp. | Desiccate at RT | | solubility | Soluble to 50 mM in DMSO | | form | Powder |
| | Desmethyl YM 298198 hydrochloride Usage And Synthesis |
| Description | Derivative of the mGlu1-selective antagonist YM 298198. | | Uses | Desmethyl-YM-298198 hydrochloride is a high-affinity, selective, and noncompetitive mGluR1 antagonist (IC50: 16 nM). Desmethyl-YM-298198 hydrochloride has analgesic effect in Streptozotocin (HY-13753)-induced hyperalgesic mice[1]. | | References | [1] Kohara A, et al. Radioligand binding properties and pharmacological characterization of 6-amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198), a high-affinity, selective, and noncompetitive antagonist of metabotropic glutamate receptor type 1. J Pharmacol Exp Ther. 2005 Oct;315(1):163-9. DOI:10.1124/jpet.105.087171 |
| | Desmethyl YM 298198 hydrochloride Preparation Products And Raw materials |
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