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OXPRENOLOL HYDROCHLORIDE

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Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel: +86-29-87569265 +86-18612256290
Email: 1056@dideu.com
Products Intro: Product Name:Oxprenolol hydrochloride
CAS:6452-73-9
Purity:99% Package:1g;1USD|10g;1USD|100g;1USD|1KG;1USD|25KG;1USD
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Products Intro: Product Name:OXPRENOLOL HYDROCHLORIDE
CAS:6452-73-9
Purity:99% Email: cherry@coreychem.com Package:1g;0.37USD
Company Name: Shaanxi Dideu Medichem Co. Ltd
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Products Intro: Product Name:OXPRENOLOL HYDROCHLORIDE USP/EP/BP
CAS:6452-73-9
Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer
Company Name: Dideu Industries Group Limited
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Products Intro: Product Name:OXPRENOLOL HYDROCHLORIDE
CAS:6452-73-9
Purity:99.9% Package:1g;1.1USD Remarks:FDA GMP CEP Approved Manufacturer
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Products Intro: Product Name:OXPRENOLOL HYDROCHLORIDE
CAS:6452-73-9
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OXPRENOLOL HYDROCHLORIDE manufacturers

OXPRENOLOL HYDROCHLORIDE Basic information
Product Name:OXPRENOLOL HYDROCHLORIDE
Synonyms:LABOTEST-BB LT00772178;1-[2-(ALLYLOXY)PHENOXY]-3-[ISOPROPYLAMINO]-2-PROPANOL HYDROCHLORIDE;OXPRENOLOL HYDROCHLORIDE;1-(o-allyloxyphenoxy)-3-isopropylamino-2-propanohydrochloride;dl-Alprenolol hydrochloride;dl-Oxprenolol hydrochloride;Laracor;Oxiprenolol hydrochloride
CAS:6452-73-9
MF:C15H24ClNO3
MW:301.81
EINECS:229-260-5
Product Categories:Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:6452-73-9.mol
OXPRENOLOL HYDROCHLORIDE Structure
OXPRENOLOL HYDROCHLORIDE Chemical Properties
Melting point 91-93°C
storage temp. Store at +4°C
solubility Very soluble in water, freely soluble in alcohol.
CAS DataBase Reference6452-73-9(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
RIDADR UN 2811 6.1 / PGIII
RTECS UA5277000
HazardClass IRRITANT
HS Code 2922190900
ToxicityLD50 oral in rat: 214mg/kg
MSDS Information
OXPRENOLOL HYDROCHLORIDE Usage And Synthesis
DescriptionOxprenolol is an orally bioavailable β-adrenergic receptor (β-AR) antagonist (Ki = 7.10 nM in a radioligand binding assay using rat heart tissue). It is non-selective and binds to both β1- and β2-ARs (Kds = 2.09 and 1.35 nM in isolated rat heart and uterus, respectively). Oxprenolol is selective for β-ARs over serotonin (5-HT) receptors in rat sarcolemmal membrane preparations (IC50s = 4.13 and 23,300 nM, respectively), but it binds to 5-HT1A receptors in rat hippocampus and 5-HT1B in rat striatum (Kis = 94.2 and 642 nM, respectively). Formulations containing oxprenolol have been used to treat hypertension and angina pectoris.
Chemical PropertiesWhite Solid
OriginatorTrasicor,Ciba Geigy ,Italy,1970
Usesβ-Adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic.
UsesAntihypertensive;Adrenergic receptor antagonist
Manufacturing Process75 grams of pyrocatechol monoallyl ether, 75 grams of epichlorohydrin, 75 grams of potassium carbonate and 400 ml of acetone are stirred and heated at the boil for 12 hours. The potassium carbonate is then filtered off. The solvent is distilled off in a water-jet vacuum. The residual oil is dissolved in ether and agitated with 2 N sodium hydroxide solution. The ether is separated, dried and distilled off. The residue is distilled in a water-jet vacuum. 3-(ortho-allyloxy-phenoxy)-1,2-epoxypropane passes over at 145° to 157°C under 11 mm Hg pressure. A solution of 15 grams of 3-(ortho-allyloxyphenoxy)-1,2-epoxypropane and 15 grams of isopropylamine in 20 ml of ethanol is refluxed for 4 hours. The excess amine and the alcohol are then distilled off under vacuum, to leave 1-isopropylamino-2-hydroxy-3-(orthoallyloxy-phenoxy)-propane which melts at 75° to 80°C after recrystallization from hexane.
Brand nameTrasicor (Novartis).
Therapeutic FunctionAntiarrhythmic
Biological ActivityNon-selective β -adrenergic antagonist.
Clinical UseBeta-1 adrenoceptor blocker:
Hypertension
Angina
Arrhythmias
Anxiety
Drug interactionsPotentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Analgesics: NSAIDs antagonise hypotensive effect.
Anti-arrhythmics: increased risk of myocardial depression and bradycardia; increased risk of bradycardia, myocardial depression and AV block with amiodarone; increased risk of myocardial depression and bradycardia with flecainide.
Antidepressants: enhanced hypotensive effect with MAOIs.
Antihypertensives: enhanced hypotensive effect; increased risk of first dose hypotensive effect with post-synaptic alpha-blockers such as prazosin; increased risk of withdrawal hypertension with clonidine; increased risk of bradycardia and AV block with diltiazem; severe hypotension and heart failure occasionally with nifedipine; asystole, severe hypotension and heart failure with verapamil.
Antimalarials: increased risk of bradycardia with mefloquine.
Antipsychotics: enhanced hypotensive effect with phenothiazines.
Cytotoxics: possible increased risk of bradycardia with crizotinib.
Diuretics: enhanced hypotensive effect.
Fingolimod: possibly increased risk of bradycardia.
Moxisylyte: possibly severe postural hypotension.
Sympathomimetics: severe hypertension with adrenaline and noradrenaline (especially with nonselective beta-blockers) and possibly with dopamine.
MetabolismOxprenolol is extensively metabolised in the liver, direct O-glucuronidation being the major metabolic pathway and oxidative reactions minor ones. Oxprenolol is excreted chiefly in the urine (almost exclusively in the form of inactive metabolites).
OXPRENOLOL HYDROCHLORIDE Preparation Products And Raw materials
Raw materialsIsopropylamine-->Epichlorohydrin
Tag:OXPRENOLOL HYDROCHLORIDE(6452-73-9) Related Product Information
3-AMINO-1-PHENOXY-2-PROPANOL HYDROCHLORIDE, 98 bucumolol hydrochloride oxprenolol OXPRENOLOL HYDROCHLORIDE 2-(Allyloxy)phenol moprolol 2-(2-HYDROXYETHOXY)PHENOL ALPRENOLOL HYDROCHLORIDE Alprenolol N-methyl-N-(3-phenoxypropyl)amine 1-AMINO-3-PHENOXY-PROPAN-2-OL 1-ALLYLOXY-2-METHOXY-BENZENE 1-AMINO-3-(2-METHOXY-PHENOXY)-PROPAN-2-OL 3-phenoxy-1-propanamine [3-(2-METHOXY-PHENOXY)-PROPYL]-METHYL-AMINE 3-(2-methoxyphenoxy)propan-1-amine 1-(2-METHOXYPHENOXY)-2-PROPANOL 3-(ISOPROPYLAMINO)-1,2-PROPANEDIOL