| Company Name: |
Shaanxi Xinyan Bomei Biotechnology Co., Ltd.
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| Tel: |
13892832556 |
| Email: |
2440688701@qq.com |
| Products Intro: |
Product Name:Alkyne-ethyl-PEG1-t-Butyl ester CAS:2100306-55-4 Purity:95% HPLC Package:1g;5g;10g;25g;100g;1kg
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| | Alkyne-ethyl-PEG1-t-Butyl ester Basic information |
| | Alkyne-ethyl-PEG1-t-Butyl ester Chemical Properties |
| Boiling point | 258.1±20.0 °C(Predicted) | | density | 0.972±0.06 g/cm3(Predicted) |
| | Alkyne-ethyl-PEG1-t-Butyl ester Usage And Synthesis |
| Description | Alkyne-ethyl-PEG1-t-Butyl ester has an alkyne group and a t-butyl protected carboxyl group. The alkyne reacts with azide compounds or biomolecules via copper catalyzed Click Chemistry to form a stable triazole linkage. Thecarboxyl group group can be deprotected under mild acidic conditions. | | Uses | Alkyne-ethyl-PEG1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Alkyne-ethyl-PEG1-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Alkyne-ethyl-PEG1-t-Butyl ester Preparation Products And Raw materials |
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