| Company Name: |
Xi'an Confluore Biological Technology Co., Ltd.
|
| Tel: |
+86-156-80926068 +86-15680926068 |
| Email: |
1924344760@qq.com |
| Products Intro: |
Product Name:t-Boc-Aminooxy-PEG4-azide
CAS:2100306-64-5
Purity:98% HPLC Package:10MG;25MG;50MG;100MG;1G;5G
|
t-Boc-Aminooxy-PEG4-azide manufacturers
|
| | t-Boc-Aminooxy-PEG4-azide Basic information |
| | t-Boc-Aminooxy-PEG4-azide Chemical Properties |
| | t-Boc-Aminooxy-PEG4-azide Usage And Synthesis |
| Description | t-Boc-Aminooxy-PEG4-azide is a click chemistry reagent with a t-Boc-aminooxy group. The azide group is reactive with alkyne, such as BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The protected aminooxy can be deprotected under mild acidic conditions. The hydrophilic PEG spacer increases solubility in aqueous media. | | Uses | Boc-Aminooxy-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-Aminooxy-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs | | References | [1] Zhao B, et al. Protein Engineering in the Ubiquitin System: Tools for Discovery and Beyond. Pharmacol Rev. 2020 Apr;72(2):380-413. DOI:10.1124/pr.118.015651 |
| | t-Boc-Aminooxy-PEG4-azide Preparation Products And Raw materials |
|