N,N,N',N'-Tetramethylazodicarboxamide

N,N,N',N'-Tetramethylazodicarboxamide Suppliers list

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Products Intro:	CAS:10465-78-8 Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G

N,N,N',N'-Tetramethylazodicarboxamide manufacturers

Versatility and Applications of N,N,N',N'-Tetramethylazodicarboxamide
N,N,N',N'-Tetramethylazodicarboxamide (TMAD) shows greater versatility in the Mitsunobu reaction compared to traditional reage....
Jun 11，2025

N,N,N',N'-Tetramethylazodicarboxamide Basic information

Product Name:	N,N,N',N'-Tetramethylazodicarboxamide
Synonyms:	Tetramethylazodicarboxamide(TMAD);1,1μ-Azobis(N,N-dimethylformamide), Azodicarboxylic acid bis(dimethylamide), Diazinedicarboxylic acid bis(N,N-dimethylamide), N,N,Nμ,Nμ-Tetramethylazodicarboxamide;Azodicarboxylic acid bis(dimethylamide), diamide, Diamide, Diazinedicarboxylic acid bis(N,N-dimethylamide), N,N,Nμ,Nμ-Tetramethylazodicarboxamide;1,1′-Azobis(N,N-dimethylformamide), Azodicarboxylic acid bis(dimethylamide);Diazenedicarboxylic acid bis(N,N-dimethylamide);Formamide, 1,1'-azobis[N,N-dimethyl-;AZODICARBOXYLIC ACID BIS[DIMETHYLAMIDE];DIAZINE-DICARBOXYLIC ACID BIS[N,N-DIMETHYLAMIDE]
CAS:	10465-78-8
MF:	C6H12N4O2
MW:	172.19
EINECS:	233-951-7
Product Categories:	proteinmod;Azodicarboxylates & Amides;Mitsunobu Reaction;Synthetic Organic Chemistry
Mol File:	10465-78-8.mol

N,N,N',N'-Tetramethylazodicarboxamide Chemical Properties

Melting point	112 °C
Boiling point	220.4±23.0 °C(Predicted)
density	1.13±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	soluble in Methanol
form	crystalline
pka	-0?+-.0.70(Predicted)
color	yellow
Water Solubility	water: 19.60-21.00mg/mL, clear to slightly hazy, orange
BRN	1910409
InChI	InChI=1S/C6H12N4O2/c1-9(2)5(11)7-8-6(12)10(3)4/h1-4H3/b8-7+
InChIKey	VLSDXINSOMDCBK-BQYQJAHWSA-N
SMILES	C(=O)(/N=N/C(=O)N(C)C)N(C)C
CAS DataBase Reference	10465-78-8(CAS DataBase Reference)

Safety Information

MSDS Information

Provider	Language
3-(N,N-Dimethylcarbamoylimido)-1,1-dimethylurea	English
SigmaAldrich	English

N,N,N',N'-Tetramethylazodicarboxamide Usage And Synthesis

Description	N,N,N’,N’-Tetramethylazodicarboxamide (also named as Diamide, TMAD) is a reagent used for the oxidization of thiols in proteins. It is used as a reagent in the Mitsunobu reaction in place of diethyl azodicarboxylate. It can be used to titrate protein gluotathiolation to discriminate from other protein modifications.
References	N. S. Kosower, E. M. Kosower, Diamide: A oxidant probe for this, Methods in Enzymology, 1995, vol. 251, pp. 123133
Chemical Properties	Yellow crystals
Uses	Reported to be of use as a thiol oxidizing agent. Diamide has been used to titrate protein glutathiolation to discriminate from other oxidative protein modifications. Treatment increased protein glutathiolation in a concentration-dependent manner and had comparably little effect on protein-protein disulfide formation.
Definition	ChEBI: 1,1'-azobis(N,N-dimethylformamide) is a monoazo compound.
Synthesis Reference(s)	The Journal of Organic Chemistry, 38, p. 1652, 1973 DOI: 10.1021/jo00949a007

N,N,N',N'-Tetramethylazodicarboxamide Preparation Products And Raw materials

Raw materials	Dichloromethane-->Triethylamine-->HYDRAZINE-->Dimethylcarbamoyl chloride-->Silver oxide
Preparation Products	1-amino-9,10-dihydro-9,10-dioxoanthracene-2-carbaldehyde 2-[(1-amino-9,10-dihydro-9,10-dioxo-2-anthryl)methylene]hydrazone-->1H-Indazole-3-diazonium, 6-chloro-

Tag:N,N,N',N'-Tetramethylazodicarboxamide(10465-78-8) Related Product Information

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