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| | CGS 15943 Basic information |
| Product Name: | CGS 15943 | | Synonyms: | CGS 15943;9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine;9-Chloro-2-(furan-2-yl)[1,2,4]triazolo[1,5-c]quinazolin-5-amine;9-Chloro-5,6-dihydro-2-(furan-2-yl)[1,2,4]triazolo[1,5-c]quinazolin-5-imine;CGS-15943A;9-CHLORO-2-(2-FURYL)(1,2,4)TRIAZOLO(1,5-C)QUINAZOLIN-5-AMINE;9-CHLORO-2-(2-FURANYL)-[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE;CGS-15943 ADENOSINE A1 RECEPTOR | | CAS: | 104615-18-1 | | MF: | C13H8ClN5O | | MW: | 285.69 | | EINECS: | | | Product Categories: | Adenosine receptor | | Mol File: | 104615-18-1.mol |  |
| | CGS 15943 Chemical Properties |
| Melting point | 278-279 °C | | density | 1.72±0.1 g/cm3(Predicted) | | storage temp. | room temp | | solubility | DMSO: >16 mg/mL | | pka | 1.23±0.30(Predicted) | | form | solid | | color | white |
| | CGS 15943 Usage And Synthesis |
| Uses | Potent adenosine receptor antagonist | | Definition | ChEBI: A member of the class of triazoloquinazolines that is [1,2,4]triazolo[1,5-c]quinazoline substited at positions 2, 5 and 9 by furan-2-yl, amino and chloro groups respectively. A potent antagonist at adenosine A1 and adenosi
e A2A receptors. | | Synthesis Reference(s) | Journal of Heterocyclic Chemistry, 27, p. 1549, 1990 DOI: 10.1002/jhet.5570270605 | | Biological Activity | Potent adenosine receptor antagonist (K i values are 3.5, 4.2, 16 and 51 nM for human A 1 , A 2A , A 2B and A 3 receptors respectively). Orally active in vivo . | | Biochem/physiol Actions | CGS-15943 is a potent and non-selective adenosine receptor antagonist. It exhibits anti-carcinogenic and anti-apoptotic activity. | | storage | Store at RT |
| | CGS 15943 Preparation Products And Raw materials |
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