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Product Name:AA 147
CAS:393121-74-9
Purity:98% Package:1G;10G;100G Remarks:AA 147 is an endoplasmic reticulum (ER) proteostasis regulator. Activates the ATF6 transcriptional program independently of ER stress and/or global UPR activation. Selectively reduces secretion of amy
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| | N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide Basic information |
| Product Name: | N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide | | Synonyms: | N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide;AA147
(AA 147;N-(2-Hydroxy-5-methylphenyl)benzenepropanamide;Benzenepropanamide, N-(2-hydroxy-5-methylphenyl)-;AA147 >=98% (HPLC);ATF6 agonist compound A147;ATF6-activator-147 (AA147);ATF6-activator-147 | | CAS: | 393121-74-9 | | MF: | C16H17NO2 | | MW: | 255.31 | | EINECS: | | | Product Categories: | | | Mol File: | 393121-74-9.mol |  |
| | N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide Chemical Properties |
| Boiling point | 460.8±40.0 °C(Predicted) | | density | 1.190±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO (>25 mg/ml); ethanol (>25 mg/mL) | | form | solid | | pka | 9.68±0.48(Predicted) | | color | Beige to pale orange | | Stability: | Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| | N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide Usage And Synthesis |
| Description | AA147 (393121-74-9) is a preferential activator of the ER stress sensing protein ATF6.1 It was able to selectively reduce secretion and extracellular aggregation of destabilized amyloidogenic variants of TTR and LC proteins. AA147-dependent ATF6 activation proceeds via metabolic activation to a reactive electrophile that selectively modifies ER proteins including multiple protein disulfide isomerases.2? AA147 suppressed pluripotency and promoted human stem cell differentiation toward a mesodermal lineage via ER expansion.3? It protected the heart against ischemia/reperfusion (I/R) injury in a mouse model of acute myocardial infarction in an ATF6-dependent manner.4 Brain, kidney, and liver tissue was also protected from I/R damage and impaired proteostasis. AA147 reduced infection of multiple strains of dengue and Zika viruses in an ATF6-independent manner.5 Protects against glutamate-induced cell death is a neuronal-derived cell culture model.6 See companion inhibitor 10-3974. | | storage | Store at +4°C | | References | Plate et al. (2016), Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation; Elife 5 e15550
Paxman et al. (2018), Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum, proteins; Elife 7 e37168
Kroeger et al. (2018), The unfolded protein response regulator ATF6 promotes mesodermal differentiation; Sci. Signal. 11 eaan5785
Blackwood et al. (2019), Pharmacological ATF6 activation confers global protection in widespread disease models by reprogramming cellular proteostasis; Nat. Commun. 10 187
Almasy et al. (2021), Small molecule endoplasmic reticulum proteostasis regulator acts as a broad-spectrum inhibitor of dengue and Zika virus infections; Proc. Natl. Acad. Sci. USA 118 e2012209118
Rosardo et al. (2021), Metabolically Activated Proteostasis Regulators against Glutamate Toxicity by Activating NRF2; ACS Chem. Biol. 16 2852 |
| | N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide Preparation Products And Raw materials |
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