葫芦素 E
中文名称 | 葫芦素 E |
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中文同义词 | 葫芦素 E;葫芦苦素E;葫芦素E(葫芦苦素E);葫芦素E(标准品);葫芦素 E, >99%;葫芦素 E, 来源于甜瓜;葫芦素E对照品;(R,E)-6-((8S,9R,10R,13R,14S,16R,17R)-2,16-二羟基-4,4,9,13,14-五甲基-3,11-二氧代-4,7,8,9,10,11,12,13,15,16,17-十二氢-3H-环戊基[A]菲-17-基)-6-羟基-2-甲基-5-氧代庚-3-烯-2-基 乙酸酯 |
英文名称 | Cucurbitacin E |
英文同义词 | A-ELATERIN;ALPHA-ELATERIN;CUCURBITACIN E;CUCURBITACIN E(SH);19-nor-9-beta,10-alpha-lanosta-1,5,23-triene-3,11,22-trione,2,16-alpha,20,25-t;25-acetate;alpha-elaterine;cucurbitacine-e |
CAS号 | 18444-66-1 |
分子式 | C32H44O8 |
分子量 | 556.69 |
EINECS号 | 242-325-2 |
相关类别 | 中草药成分;中药对照品;标准品;植物提取物;对照品;reference standards from Chinese medicinal herbs (TCM).;植提标准品;分析对照品;分析试剂标准品;标准品-对照品;标准品-中药标准品;标准品 -中药标准品;三萜;标准品,对照品;苦味素;Tri-Terpenoids;chemical reagent;pharmaceutical intermediate;phytochemical;standardized herbal extract |
Mol文件 | 18444-66-1.mol |
结构式 |
葫芦素 E 性质
熔点 | 228-234°C |
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比旋光度 | D -59° (c = 0.7 in chloroform) |
沸点 | 545.56°C (rough estimate) |
密度 | 1.1059 (rough estimate) |
折射率 | 1.4900 (estimate) |
储存条件 | -20°C |
溶解度 | DMSO:可溶15mg/mL,澄清 |
形态 | 粉末 |
酸度系数(pKa) | 8.51±0.70(Predicted) |
颜色 | 白色至米色 |
旋光性 (optical activity) | [α]/D -60 to -75°, c = 0.7 (CDCl3) |
InChIKey | NDYMQXYDSVBNLL-MUYMLXPFSA-N |
LogP | 3.150 (est) |
cyclin B1/CDC2
|
Autophagy
|
To explore the antitumor activity of Cucurbitacin E (CuE) against colorectal cancer (CRC) cells, an in vitro study is initiated in which each of the CRC cell lines is exposed to increasing doses of Cucurbitacin E (0, 2.5, 5, and 7.5 μM) over a period of 24 h. The proliferation of the Cucurbitacin E-treated cancer cells is then measured using the MTT method. Cucurbitacin E is shown to induce morphological changes in the primary colon cancer cells. Microscopic observation showed that following exposure to Cucurbitacin E (5 μM) between 6 and 24 h, the primary colon cancer cells underwent a remarkable change in morphology. Cucurbitacin E inhibits tumor growth by arresting the cell cycle in the G 2 /M phase via GADD45γ gene expression and the blockage of cyclin B1/CDC2 complex in primary CRC cells.
A high fat diet mice model of metabolic syndrome (HFD-MetS) is developed to assess the role of Cucurbitacin E (CuE) on body weight and fat tissue biology. Significant decrease in body weights of HFD-MetS mice treated with Cucurbitacin E (0.5mg/kg) are found as compared to HFD-MetS mice treated with vehicle alone. Cucurbitacin E treatment reduces all fat pads weights in HFD-MetS mice. 55% reduction is observed in total fat in mice, after treatment with Cucurbitacin E in comparison to HFD-MetS mice. Abdominal obesity is strongly associated with metabolic syndrome. Central obesity is reduced to 50% after Cucurbitacin E treatment as compared to HFD MetS mice, elucidating the effectiveness of Cucurbitacin E in targeting MetS.
药理药效:用于治疗慢性肝炎。1细胞毒与抗癌作用,2抗肝损害,3提高机体免疫功能。
安全信息
危险品标志 | Xn |
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危险类别码 | 25-22 |
安全说明 | 1-22-45-24/25 |
危险品运输编号 | 3172 |
WGK Germany | 3 |
RTECS号 | RC6305500 |
海关编码 | 29153900 |
毒性 | LD50 orally in mice: 340 mg/kg (Albert) |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/01/25 | HY-N0417 | Cucurbitacin E | 1 mg | 548元 | |
2024/01/25 | HY-N0417 | 葫芦素 E Cucurbitacin E | 18444-66-1 | 5mg | 1200元 |