1-[4-[3-[4-(1H-benzimidazole-2-carbonyl)phenoxy]pyrazin-2-yl]piperidin-1-yl]ethanone

1-[4-[3-[4-(1H-benzimidazole-2-carbonyl)phenoxy]pyrazin-2-yl]piperidin-1-yl]ethanone Suppliers list

Company Name:	TargetMol Chemicals Inc.
Tel:	+1-781-999-5354; +17819995354
Email:	marketing@targetmol.com
Products Intro:	Product Name:AMG 579 CAS:1227067-61-9 Purity:99.35% Package:1mg;30USD\|2mg;39USD\|5mg;67USD Remarks:REAGENT;FOR LABORATORY USE ONLY

Company Name:	HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel:	86-571-88216897,88216896 13588875226
Email:	sales@hzclap.com
Products Intro:	Product Name:1-[4-[3-[4-(1H-benzimidazole-2-carbonyl)phenoxy]pyrazin-2-yl]piperidin-1-yl]ethanone CAS:1227067-61-9 Purity:34499% Package:10kg 25kg 200 kilograms per barrel Remarks:good

Company Name:	InvivoChem
Tel:	+1-708-310-1919 +1-13798911105
Email:	sales@invivochem.cn
Products Intro:	Product Name:AMG-579 CAS:1227067-61-9 Purity:98% Package:5mg Remarks:V3461

Company Name:	TargetMol Chemicals Inc.
Tel:	+1-781-999-5354;
Email:	support@targetmol.com
Products Intro:	Product Name:AMG 579 CAS:1227067-61-9 Purity:99.35% Package:1mg;30USD\|2mg;39USD\|5mg;67USD

Company Name:	Aladdin Scientific
Tel:
Email:	tp@aladdinsci.com
Products Intro:	Product Name:AMG 579 CAS:1227067-61-9 Purity:99% Package:$175.9/5mg;$275.9/10mg;$825.9/50mg;$1125.9/100mg;Bulk package Remarks:99%

1-[4-[3-[4-(1H-benzimidazole-2-carbonyl)phenoxy]pyrazin-2-yl]piperidin-1-yl]ethanone manufacturers

1-[4-[3-[4-(1H-benzimidazole-2-carbonyl)phenoxy]pyrazin-2-yl]piperidin-1-yl]ethanone Basic information

Product Name:	1-[4-[3-[4-(1H-benzimidazole-2-carbonyl)phenoxy]pyrazin-2-yl]piperidin-1-yl]ethanone
Synonyms:	1-[4-[3-[4-(1H-benzimidazole-2-carbonyl)phenoxy]pyrazin-2-yl]piperidin-1-yl]ethanone;Ethanone, 1-[4-[3-[4-(1H-benzimidazol-2-ylcarbonyl)phenoxy]-2-pyrazinyl]-1-piperidinyl]-;AMG 579, 10 mM in DMSO
CAS:	1227067-61-9
MF:	C25H23N5O3
MW:	441.48
EINECS:
Product Categories:
Mol File:	1227067-61-9.mol

1-[4-[3-[4-(1H-benzimidazole-2-carbonyl)phenoxy]pyrazin-2-yl]piperidin-1-yl]ethanone Chemical Properties

Safety Information

MSDS Information

1-[4-[3-[4-(1H-benzimidazole-2-carbonyl)phenoxy]pyrazin-2-yl]piperidin-1-yl]ethanone Usage And Synthesis

Uses	AMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 of 0.1 nM.
in vivo	AMG 579 shows statistically significant reduction of PCP induced behavior in rats over the 2 h period. Minimum effective doses for efficacy in PCP-LMA model is determined to be 0.3 mg/kg for AMG 579. In dog, 5 exhibits superior oral bioavailability of 72%^[1].
References	[1] Hu E,et al. Discovery of clinical candidate 1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A). J Med Chem. 2014 Aug 14;57(15 DOI:10.1021/jm500713j

1-[4-[3-[4-(1H-benzimidazole-2-carbonyl)phenoxy]pyrazin-2-yl]piperidin-1-yl]ethanone Preparation Products And Raw materials

Tag:1-[4-[3-[4-(1H-benzimidazole-2-carbonyl)phenoxy]pyrazin-2-yl]piperidin-1-yl]ethanone(1227067-61-9) Related Product Information

HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.