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Cefazolin

Cefazolin Suppliers list
Company Name: Henan Tianfu Chemical Co.,Ltd.
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Products Intro: Product Name:25953-19-9
CAS:25953-19-9
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: Xiamen AmoyChem Co., Ltd
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Products Intro: Product Name:cefamezin
CAS:25953-19-9
Company Name: HubeiwidelychemicaltechnologyCo.,Ltd
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Products Intro: Product Name:Cefazolin
CAS:25953-19-9
Purity:0.99 Package:4/5kg 4/5kg Aluminum Hearing
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Products Intro: Product Name:Cefazolin
CAS:25953-19-9
Purity:0.99 Package:5KG;1KG
Company Name: BOC Sciences
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Products Intro: Product Name:Cefazolin
CAS:25953-19-9
Purity:98% Package:1G;10G;100G Remarks:Cefazolin is an antibiotic used to treat a wide variety of bacterial infections. It may also be used before and during certain surgeries to help prevent infection. Cefazolin is a semisynthetic cephalo

Cefazolin manufacturers

  • Cefazolin
  • $10.00 / Kg/Bag
  • 2021-11-13
  • CAS:25953-19-9
  • Min. Order: 1Kg/Bag
  • Purity: 99%
  • Supply Ability: 20 Tons
  • cefazolin
  • $15.00-10.00 / KG
  • 2021-07-02
  • CAS:25953-19-9
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
  • Cefazolin USP/EP/BP
  • $1.10 / g
  • 2021-07-01
  • CAS:25953-19-9
  • Min. Order: 1g
  • Purity: 99.9%
  • Supply Ability: 100 Tons Min
Cefazolin Basic information
Product Name:Cefazolin
Synonyms:CEFAZOLIN;CEFAZOLIN ACID;(6r-trans)-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[[(1h-tetr;5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid,3-(((5-methyl-1,3,4-thia;(6R,7R)-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[[1-oxo-2-(1-tetrazolyl)ethyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;7-(1-(1h-)-tetrazolylacetamido)-3-[2-(5-methyl-1,3,4-thiadiazolyl)thiomethyl]d;azol-1-yl)acetyl]-amino]-5-thia-1-azabicylo;cefamezin
CAS:25953-19-9
MF:C14H14N8O4S3
MW:454.51
EINECS:247-362-8
Product Categories:
Mol File:25953-19-9.mol
Cefazolin Structure
Cefazolin Chemical Properties
Melting point 198-200 C
density 2.01±0.1 g/cm3(Predicted)
pkapKa 2.15 (Uncertain)
form neat
CAS DataBase Reference25953-19-9(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22-36/37/38
Safety Statements 26-36
WGK Germany 3
HS Code 2941906000
Hazardous Substances Data25953-19-9(Hazardous Substances Data)
MSDS Information
ProviderLanguage
Cefazolin English
Cefazolin Usage And Synthesis
DescriptionCefazolin has the natural acetyl side chain at C-3 replaced by a thio-linked thiadiazole ring. Although this group is an activating leaving group, the moiety is not subject to the inactivating host hydrolysis reaction that characterizes cephapirin. At C-7, it possesses a tetrazoylmethylene unit. Cefazolin is less irritating on injection than its cohort in this generation of drugs and has a longer half-life than cephapirin. Its dosing should be reduced in the presence of renal impairment. It is comparatively unstable and should be protected from heat and light.
Chemical Propertiesneedles
OriginatorCefamedin,Fujisawa,Japan,1971
UsesCefazolin is an antibacterial compound derived from 7-amino-cephalosporanic acid.
UsesAntibacterial (systemic).
DefinitionChEBI: A cephalosporin compound having [(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl and (1H-tetrazol-1-ylacetyl)amino side-groups.
Manufacturing Process7-Aminocephalosporanic acid is converted to its sodium salt and acylated with 1H-tetrazole-1-acetyl chloride. The acetoxy group is then displaced by reaction with 5-methyl-1,3,4-thiadiazole-2-thiol in buffer solution. The product acid is converted to the sodium salt by NaHCO3.
Therapeutic FunctionAntibacterial
Antimicrobial activityEnterobacter, Klebsiella, Providencia, Serratia spp. and Pr. vulgaris are all resistant. B. fragilis is resistant, but other anaerobes are susceptible.
PharmacokineticsDistribution
The volume of distribution is the smallest of the cephalosporins in group 1, perhaps an indication of relative confinement to the plasma space. It crosses inflamed synovial membranes, but the levels achieved are well below those of the simultaneous serum levels and entry to the CSF is poor. In patients receiving 10 mg/kg by intravenous bolus, mean concentrations in cancellous bone were 3.0 mg/kg when the mean serum concentration was 33 mg/L, giving a bone:serum ratio of 0.09. Some crosses the placenta, but the concentrations found in the fetus and membranes are low.
Metabolism and excretion
It is not metabolized. Around 60% of the dose is excreted in the urine within the first 6 h, producing concentrations in excess of 1 g/L. Excretion is depressed by probenecid. The renal clearance is around 65 mL/min and declines in renal failure, when the half-life may rise to 40 h, although levels in the urine sufficient to inhibit most urinary pathogens are still found. It is moderately well removed by hemodialysis and less well by peritoneal dialysis.
Levels sufficient to inhibit a number of enteric organisms likely to infect the biliary tract are found in T-tube bile (17–31 mg/L after a 1 g intravenous dose), but this is principally due to the high serum levels of the drug and the total amounts excreted via the bile are small.
Clinical UseCefazolin has been widely used in surgical prophylaxis, especially in biliary tract (because of the moderately high concentrations achieved in bile), orthopedic, cardiac and gynecological surgery.
Side effectsSide effects are those common to other cephalosporins ,including rare bleeding disorders and encephalopathy in patients in whom impaired excretion or direct instillation leads to very high CSF levels. Neutropenia has been described and hypoprothrombinemic bleeding has been attributed to the side chain.
Chemical SynthesisCefazolin, (6R-trans)-3[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo- 7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabycyclo[4.2.0]oct-2-en-2-carboxylic acid (32.1.2.7), is synthesized by reacting 7-aminocephalosporanic acid with a mixed anhydride (32.1.2.6), which is the result of a reaction of tetrazolylacetic acid with pivalic (trimethylacetic) acid chloride. Further reaction with 2-mercapto-5-methyl-1,3,4-thiadiazole results in a substitution of the 3-acetoxy group with a mercaptothiadiazol group, giving cefazolin (32.1.2.7).

Tag:Cefazolin(25953-19-9) Related Product Information
7-TDA / for Cefazolin & Cefazedone cefazolin delta-2-methyl ester CEFAZOLIN SODIUM FOR INJECTION Cefazolin Sodium Sterile/Oral CEFAZOLIN SODIUMIMP. E (EP): 5-METHYL-1,3,4-THIADIAZOL-2-THIOL (MMTD) 7-AMINO-3-CHLOROMETHYL-3-CEPHEM-4-CARBOXYLIC ACID P-METHOXYBENZYL ESTER, HYDROCHLORIDE cefazolin delta-3-methyl ester TETRAZOLE-1-ACETIC ACID CEFAZOLIN CEFTEZOLE 7-(5-amino-5-carboxyvaleramido)cephalosporanic acid Ceftezole sodium Quinazoline Methyl Oxymetazoline (2-acetoxyethyl)trimethylammonium Ceftezole 7-Amino-3-[(5-methyl-1,3,4-thiadiazol-2-ylthio)methyl]-3-cephem-4-carboxylic Acid Naphazoline hydrochloride 2,1,3-Benzothiadiazole