ChemicalBook > Product Catalog >API >Antibiotics >Cephalosporins Drugs >Cefazolin


Cefazolin Suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Products Intro: Product Name:Cefazolin
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Products Intro: CAS:25953-19-9
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Mainchem Co., Ltd.
Tel: +86-0592-6210733
Products Intro: Product Name:Cefazolin
Company Name: Xiamen AmoyChem Co., Ltd
Tel: +86 (0)592-605 1114
Products Intro: Product Name:cefamezin
Company Name: Chemwill Asia Co.,Ltd.
Tel: 86-21-51086038
Products Intro: CAS:25953-19-9
Purity:99% Package:5KG;1KG;25KG PRICE quotation Remarks:Factory stock, quality assurance, price concessions
Cefazolin Basic information
Product Name:Cefazolin
Synonyms:CEFAZOLIN;CEFAZOLIN ACID;(6r-trans)-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[[(1h-tetr;5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid,3-(((5-methyl-1,3,4-thia;7-(1-(1h-)-tetrazolylacetamido)-3-[2-(5-methyl-1,3,4-thiadiazolyl)thiomethyl]d;azol-1-yl)acetyl]-amino]-5-thia-1-azabicylo;cefamezin;CefazoilnV
Product Categories:-
Mol File:25953-19-9.mol
Cefazolin Structure
Cefazolin Chemical Properties
Melting point 198-200 C
pkapKa 2.15 (Uncertain)
form neat
CAS DataBase Reference25953-19-9(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22-36/37/38
Safety Statements 26-36
WGK Germany 3
Hazardous Substances Data25953-19-9(Hazardous Substances Data)
MSDS Information
Cefazolin English
Cefazolin Usage And Synthesis
Chemical Propertiesneedles
UsesAntibacterial (systemic).
DefinitionChEBI: A cephalosporin compound having [(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl and (1H-tetrazol-1-ylacetyl)amino side-groups.
Antimicrobial activityEnterobacter, Klebsiella, Providencia, Serratia spp. and Pr. vulgaris are all resistant. B. fragilis is resistant, but other anaerobes are susceptible.
The volume of distribution is the smallest of the cephalosporins in group 1, perhaps an indication of relative confinement to the plasma space. It crosses inflamed synovial membranes, but the levels achieved are well below those of the simultaneous serum levels and entry to the CSF is poor. In patients receiving 10 mg/kg by intravenous bolus, mean concentrations in cancellous bone were 3.0 mg/kg when the mean serum concentration was 33 mg/L, giving a bone:serum ratio of 0.09. Some crosses the placenta, but the concentrations found in the fetus and membranes are low.
Metabolism and excretion
It is not metabolized. Around 60% of the dose is excreted in the urine within the first 6 h, producing concentrations in excess of 1 g/L. Excretion is depressed by probenecid. The renal clearance is around 65 mL/min and declines in renal failure, when the half-life may rise to 40 h, although levels in the urine sufficient to inhibit most urinary pathogens are still found. It is moderately well removed by hemodialysis and less well by peritoneal dialysis.
Levels sufficient to inhibit a number of enteric organisms likely to infect the biliary tract are found in T-tube bile (17–31 mg/L after a 1 g intravenous dose), but this is principally due to the high serum levels of the drug and the total amounts excreted via the bile are small.
Clinical UseCefazolin has been widely used in surgical prophylaxis, especially in biliary tract (because of the moderately high concentrations achieved in bile), orthopedic, cardiac and gynecological surgery.
Side effectsSide effects are those common to other cephalosporins ,including rare bleeding disorders and encephalopathy in patients in whom impaired excretion or direct instillation leads to very high CSF levels. Neutropenia has been described and hypoprothrombinemic bleeding has been attributed to the side chain.
Tag:Cefazolin(25953-19-9) Related Product Information
Acetazolamide Quinazoline 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Basic Violet 1 Methyl acrylate Methyl Methyl acetate Oxymetazoline (2-acetoxyethyl)trimethylammonium Ceftezole 7-Amino-3-[(5-methyl-1,3,4-thiadiazol-2-ylthio)methyl]-3-cephem-4-carboxylic Acid Naphazoline hydrochloride 2,1,3-Benzothiadiazole Methanol Cefazolin sodium sterile,CEFAZOLIN NA,CEFAZOLIN SODIUM,CEFAZOLIN SODIUM SALT Paraquat dichloride Kresoxim-methyl 2-Mercapto-5-methyl-1,3,4-thiadiazole