3-(3,4-dimethoxyphenyl)-7-{2-[4-(2-hydroxyethyl)-1-piperazinyl]ethoxy}-4-methyl-2H-chromen-2-one

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3-(3,4-dimethoxyphenyl)-7-{2-[4-(2-hydroxyethyl)-1-piperazinyl]ethoxy}-4-methyl-2H-chromen-2-one Basic information
Product Name:3-(3,4-dimethoxyphenyl)-7-{2-[4-(2-hydroxyethyl)-1-piperazinyl]ethoxy}-4-methyl-2H-chromen-2-one
Synonyms:3-(3,4-dimethoxyphenyl)-7-{2-[4-(2-hydroxyethyl)-1-piperazinyl]ethoxy}-4-methyl-2H-chromen-2-one;2H-1-Benzopyran-2-one, 3-(3,4-dimethoxyphenyl)-7-[2-[4-(2-hydroxyethyl)-1-piperazinyl]ethoxy]-4-methyl-
CAS:921099-13-0
MF:C26H32N2O6
MW:468.54
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Mol File:921099-13-0.mol
3-(3,4-dimethoxyphenyl)-7-{2-[4-(2-hydroxyethyl)-1-piperazinyl]ethoxy}-4-methyl-2H-chromen-2-one Structure
3-(3,4-dimethoxyphenyl)-7-{2-[4-(2-hydroxyethyl)-1-piperazinyl]ethoxy}-4-methyl-2H-chromen-2-one Chemical Properties
Boiling point 659.5±55.0 °C(Predicted)
density 1+-.0.06 g/cm3(Predicted)
form Solid
pka14.96±0.10(Predicted)
color Off-white to light brown
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MSDS Information
3-(3,4-dimethoxyphenyl)-7-{2-[4-(2-hydroxyethyl)-1-piperazinyl]ethoxy}-4-methyl-2H-chromen-2-one Usage And Synthesis
UsesTM-1 is a potent inhibitor of pyruvate dehydrogenase kinase (PDHK1). TM-1 inhibits PDHK1 and PDHK2 with IC50s of 2.97 μM and 5.2 μM, respectively. TM-1 blocks pyruvate dehydrogenase complex (PDHC) phosphorylation, and inhibits cell proliferation[1].
References[1] Fang A, et al. Identification of pyruvate dehydrogenase kinase 1 inhibitors with anti-osteosarcoma activity. Bioorg Med Chem Lett. 2017 Dec 15;27(24):5450-5453. DOI:10.1016/j.bmcl.2017.10.073
3-(3,4-dimethoxyphenyl)-7-{2-[4-(2-hydroxyethyl)-1-piperazinyl]ethoxy}-4-methyl-2H-chromen-2-one Preparation Products And Raw materials
Tag:3-(3,4-dimethoxyphenyl)-7-{2-[4-(2-hydroxyethyl)-1-piperazinyl]ethoxy}-4-methyl-2H-chromen-2-one(921099-13-0) Related Product Information
3-(3,4-dimethoxyphenyl)-2-oxo-2H-chromen-7-yl acetate 3-(3,4-dimethoxyphenyl)-7-{2-[4-(2-hydroxyethyl)piperazin-1-yl]ethoxy}-2H-chromen-2-one 2-morpholinoethyl 8-methoxy-2-oxo-2H-chromene-3-carboxylate 8-[(dimethylazaniumyl)methyl]-4-methyl-2-oxo-3-phenylchromen-7-olate AP2238 2H-1-Benzopyran-2-one, 7-(diethylamino)-3-(3,4-dimethoxyphenyl)-