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Tafluprost

Tafluprost Suppliers list
Company Name: Shanghai finete Pharmaceutical Co., Ltd.
Tel: +86-18221039705
Email: sales@finetechpharm.com
Products Intro: Product Name:Tafluprost
CAS:209860-87-7
Purity:99% HPLC Package:1g; 10g; 100g ; Remarks:Prostaglandins
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:209860-87-7
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: 008615858145714
Email: fandachem@gmail.com
Products Intro: Product Name:Tafluprost fandachem
CAS:209860-87-7
Purity:As coa Package:As request Remarks:209860-87-7
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +86 21 5161 9050/ 5187 7795
Email: ivan@atkchemical.com
Products Intro: CAS:209860-87-7
Purity:98% HPLC Package:5G;10G;25G;50G;100G;250G;1KG
Company Name: Shanghai Zheyan Biotech Co., Ltd.
Tel: 18017610038
Email: zheyansh@163.com
Products Intro: Product Name:Tafluprost
CAS:209860-87-7
Purity:97% Package:5g;25g;100g

Lastest Price from Tafluprost manufacturers

  • Tafluprost
  • US $10.00 / Kg/Bag
  • 2021-04-21
  • CAS:209860-87-7
  • Min. Order: 1Kg/Bag
  • Purity: 99%min
  • Supply Ability: 2000
  • Tafluprost
  • US $0.00 / KG
  • 2021-03-18
  • CAS:209860-87-7
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 200000pcs
  • Tafluprost
  • US $1.00 / kg
  • 2019-07-06
  • CAS:209860-87-7
  • Min. Order: 1kg
  • Purity: 95%-99%
  • Supply Ability: 100kg
Tafluprost Basic information
Product Name:Tafluprost
Synonyms:209860-87-7;He has fluprostaglandin;TAFLUPROST;(5Z)-7-[(1R,2R,3R,5S)-2-[(1E)-3,3-Difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-5-heptenoic acid 1-methylethyl ester;15,15-DIFLUORO-9ALPHA,11ALPHA-DIHYDROXY-16-PHENOXY-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC ACID, ISOPROPYL ESTER;AFP-168;Tafluprost5-Heptenoic acid, 7-[(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-,1-methylethyl ester, (5Z)-;MK2452
CAS:209860-87-7
MF:C25H34F2O5
MW:452.53
EINECS:
Product Categories:
Mol File:209860-87-7.mol
Tafluprost Structure
Tafluprost Chemical Properties
Boiling point 552.9±50.0 °C(Predicted)
density 1.186
pka14.48±0.70(Predicted)
Safety Information
MSDS Information
Tafluprost Usage And Synthesis
DescriptionGlaucoma is second only to cataracts as a causative factor of blindness. By 2010, it is estimated that approximately 60 million people worldwide will be afflicted by glaucoma, so effective treatments should garner a large market. PG analogs have been widely used for lowering IOP by increasing uveoscleral outflow through agonism of the prostanoid FP receptor, and currently marketed versions include latanoprost, unoprostone isopropyl ester, bimatoprost, and travoprost. Compared to the carboxylic acid of latanaprost (Ki=4.7 nM), the carboxylic acid of tafluprost displayed a 10-fold greater affinity for the prostanoid FP receptor (Ki=0.4 nM). The synthesis of tafluprost begins with a Wittig condensation of the protected bicyclic lactone carbaldehyde with a dimethyl phosphonate ketone derivative.
Compared to the carboxylic acid of latanaprost (Ki 4.7 nM), the carboxylic acid of tafluprost displayed a 10-fold greater affinity for the prostanoid FP receptor (Ki 0.4 nM). The synthesis of tafluprost begins with a Wittig condensation of the protected bicyclic lactone carbaldehyde with a dimethyl phosphonate ketone derivative. The bottom appendage is then completed by the fluorination of the ketone with morpholino-sulfur trifluoride. Hydrolysis of the benzoate ester protecting group liberates the hydroxy group, and reduction of the lactone is accomplished with aluminum hydride to generate the lactol. Condensation of this intermediate with the phosphonium salt of the acid side chain generates the free acid, or active ingredient, which is subsequently esterified with 2-iodopropane in the presence of DBU. .
OriginatorSanten/Asahi Glass (Japan)
UsesTafluprost is a novel prostanoid used in the treatment of glaucoma and is the first prostanoid to be released in a preservative free-formula.
DefinitionChEBI: A prostaglandin Falpha that is prostaglandin F2alpha in which the carboxylic acid function has been converted to the corresponding isopropyl ester and the 3-hydroxy-1-octenyl side- hain is substituted by 3,3-difluoro-4-phenoxybut-1-enyl. Used for treatment of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
Brand nameTaflotan
Chemical SynthesisThe synthesis was initiated from the Corey aldehyde 131. Horner-Emmons condensation of the bicyclic carbaldehyde 131 with the dimethyl phosphonate 132 using NaH in DMF gave enone 133 in 90% yield. Fluorination of the enone 133 was accomplished upon reaction with morpholino-sulfur trifluoride (134) in chloroform to yield the corresponding difluorinated compound 135. Hydrolysis of the benzoate ester group of 135 with K2CO3 in methanol at room temperature afforded alcohol 136 in 71% yield from 133. Reduction of the lactone group of 136 with diisobutyl aluminum hydride (DIBAL) in THF/toluene gave lactol 137 in 83% yield. Lactol 137 was condensed with the phosphonium ylide prepared by deprotonation of phosphonium salt 138 with sodium bis(trimethylsilyl)amide (NaHMDS) in THF/toluene to give the prostaglandin F2-alpha derivative 139 in excellent Z/E selectivity (99:1). The synthesis was completed by esterification of compound 139 with isopropyl iodide and DBU in acetone to provide tafluprost (XVIII) in 72% yield.

Tafluprost Preparation Products And Raw materials
Tag:Tafluprost(209860-87-7) Related Product Information
Dapoxetine 9ALPHA,11ALPHA-DIHYDROXY-15,15-DIFLUORO-16-PHENOXY-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC ACID Travoprost Zonisamide Latanoprost Pirfenidone Vildagliptin Anagrelide hydrochloride 3-HEPTENOIC ACID Tafluprost Maleic acid Prostaglandin E1 Fumaric acid Maleic anhydride Polybutene Prostaglandin E2 1-BUTENE 3-BUTENE-1,2-DIOL