| Company Name: |
Riedel-de Haen AG
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| Tel: |
800 558-9160 |
| Email: |
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| Products Intro: |
Product Name:Monoclonal Anti-HIF-1α antibody produced in mouse
Remarks:Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
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| Company Name: |
SIGMA-RBI
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| Tel: |
800 736 3690 (Orders) |
| Email: |
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| Products Intro: |
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| | ANTI-HIF-1ALPHA Basic information |
| Product Name: | ANTI-HIF-1ALPHA | | Synonyms: | MOUSE ANTI-HUMAN/MOUSE/RAT/FERRET/SHEEP HIF1ALPHA;MOUSE ANTI-HUMAN/MOUSE/RAT/FERRET/SHEEP HYPOXIA INDUCIBLE FACTOR 1 ALPHA;MONOCLONAL ANTI-HYPOXIA INDUCIBLE FACTOR 1, ALPHA SUBUNIT;MONOCLONAL ANTI-HIF-1ALPHA;ANTI-HYPOXIA-INDUCIBLE FACTOR-1ALPHA;ANTI-HYPOXIA INDUCIBLE FACTOR 1ALPHA (C-TERM);ANTI-HYPOXIA-INDUCIBLE FACTOR 1ALPHA, HUMAN;ANTI-HYPOXIA-INDUCIBLE FACTOR 1ALPHA, HUMAN (MOUSE) | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-HIF-1ALPHA Structure]() |
| | ANTI-HIF-1ALPHA Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous solution |
| | ANTI-HIF-1ALPHA Usage And Synthesis |
| Uses | Monoclonal anti-HIF-1α antibody (diluted 1: 500) can be used in immunofluorescence confocal microscopy. It can also be used in in immunoblotting, immunoprecipitation and immunohistochemistry. | | Uses | Rabbit polyclonal anti-HIF1A antibody is used to tag hypoxia-inducible factor 1 α for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques such as immunoblotting, immunoprecipitation, and immunofluorescence. It is used as a probe to determine the presence and roles of hypoxia-inducible factor 1 α in the structure and function of hypoxia-inducible factor 1. | | General Description | The gene encoding HIF1A (hypoxia inducible factor 1 subunit α) is localized on human chromosome 14q23.2. It is part of the HIF-1 heterodimer complex and is modulated by oxygen. | | Biochem/physiol Actions | Hypoxia-inducible factor-1(HIF1) plays an essential role in cellular and systemic homeostatic responses to hypoxia. During hypoxia, the two subunits of this factor undergo post-translational modifications which in turn promote transactivation. HIF-1α gene loss is associated with development of nonpapillary renal carcinomas. The encoded protein functions as a key regulator of the vascular endothelial growth factor (VEGF) under hypoxic response in human stromal cells in vitro. HIF-1α protein expression is often seen in invasive breast cancer. Experimental data demonstrates that downregulation of HIF-1α decreases tumorigenicity of MCF-7 (human breast adenocarcinoma cell line) cells and propose a promising combination of both anti-HIF-1 strategy and traditional chemotherapy to improve cancer treatment. |
| | ANTI-HIF-1ALPHA Preparation Products And Raw materials |
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